Sleep, Circadian Rhythm & Skin Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Evaluation of skin (both in terms of skin aging and skin disease)
研究概览
简要总结
The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Males or females ages 18 years and above
- •Capable of giving informed consent
- •Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses
- •Fitzpatrick Skin Type I-VI
- •In good general health
- •Willing to cooperate with study instructions
排除标准
- •Volunteers 18 years or younger
- •Any serious medical or physical condition that would cause the subject significant discomfort with study procedures
- •Women who are pregnant, nursing, or who may become pregnant in the next 3 months
结局指标
主要结局
Evaluation of skin (both in terms of skin aging and skin disease)
时间窗: Only once during the study or at specific time points depending on what other procedures are being performed
The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings.
Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires
时间窗: 7-14 days
The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study.
次要结局
- MED Testing & Recovery from UV-induced erythema(24 hours)
- Sample Analysis (from skin, blood, urine, saliva and hair follicle samples)(Only once during the study or at specific time points depending on what other procedures are being performed)
- Skin Barrier Recovery (via TEWL measurement)(Only once during the study or at specific time points depending on what other procedures are being performed)
研究者
Dr. Kevin Cooper
Principal Investigator
University Hospitals Cleveland Medical Center