Sleep, Circadian Rhythm & Skin Health
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- Evaluation of skin (both in terms of skin aging and skin disease)
Study Overview
Brief Summary
The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Other
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Males or females ages 18 years and above
- •Capable of giving informed consent
- •Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses
- •Fitzpatrick Skin Type I-VI
- •In good general health
- •Willing to cooperate with study instructions
Exclusion Criteria
- •Volunteers 18 years or younger
- •Any serious medical or physical condition that would cause the subject significant discomfort with study procedures
- •Women who are pregnant, nursing, or who may become pregnant in the next 3 months
Outcomes
Primary Outcomes
Evaluation of skin (both in terms of skin aging and skin disease)
Time Frame: Only once during the study or at specific time points depending on what other procedures are being performed
The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings.
Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires
Time Frame: 7-14 days
The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study.
Secondary Outcomes
- MED Testing & Recovery from UV-induced erythema(24 hours)
- Sample Analysis (from skin, blood, urine, saliva and hair follicle samples)(Only once during the study or at specific time points depending on what other procedures are being performed)
- Skin Barrier Recovery (via TEWL measurement)(Only once during the study or at specific time points depending on what other procedures are being performed)
Investigators
Dr. Kevin Cooper
Principal Investigator
University Hospitals Cleveland Medical Center