High-intensity Interval Training is Associated With Greater Impact on Physical Fitness, Insulin Sensitivity and Muscle Mitochondrial Content in Overweight Males, as Opposed to Continuous Endurance Training: a Randomized Controlled Trial.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 主要终点
- Insulin sensitivity measured by oral glucose tolerance test
研究概览
简要总结
Background and aims: The purpose of this study was to evaluate the effect of high intensity interval training (HIIT) on body composition, physical fitness, metabolic fitness and muscle histology in men with overweight or obesity compared to continuous aerobic training (CAT).
Material and methods: 16 male participants with overweight/obesity (age range: 42 - 57 years, body mass index: 28 - 36 kg/m²) were randomized to HITT (n=8) or CAT (n=8). HIIT was composed of two sprint blocks of 10 minutes at ventilatory threshold (VT), within between a continuous block of 10 minutes, twice a week for 15 weeks. CAT was composed of three blocks of 10 minutes continuous endurance training at VT. After 5 weeks, intensity was increased to 110% of VT. Changes in body composition, physical fitness (peakVO2 and anaerobic threshold (AT)), basal respiratory exchange ratio (bRER) and insulin sensitivity by oral glucose tolerance test were evaluated. Mitochondrial content was evaluated by transmission electron microscopy (TEM) in muscle biopsies.
详细描述
Participants:
For this study, 16 adult males with overweight or obesity (BMI-range 28 - 36 kg/m2) were recruited and randomized in two experimental groups (high intensity training (n=8) and continuous moderate-intense aerobic training (n=8)). Randomization was done with the envelope method. Participants were excluded if they had diabetes (HbA1c>6,5%), severe musculoskeletal (eg osteoarthritis), cardiovascular (eg chronic heart failure) or respiratory (eg chronic obstructive pulmonary disease (COPD)) problems, based on medical files A signed informed consent was provided by all participants before study admission. The study was approved by the ethics committee of the Ghent University Hospital (B670201318620).
Intervention:
The intervention group performed a high intensity interval training [HIIT]. The HIIT group followed a 10-week training program. The participants exercised for 40 minutes, twice a week, under supervision of two physiotherapists. Each training session included a warming up [stretching of the large muscle groups and cardiovascular exercises at 30% of peak cycling power output for five minutes], a sprint interval block [10 minutes], continuous aerobic exercise [10 minutes], another sprint interval block [10 minutes] and cooling down [stretching of the large muscle groups and cardiovascular exercises at 30% of peak Watt for 5 minutes]. For the first 5 weeks, each sprint interval block consisted of 10 sprint bouts [>100 r/min] of 15 seconds at a cycling resistance matching with the ventilatory threshold [VTR], alternated with 45 seconds relative rest [50 r/min at VTR]. Starting from week 6 until week 10, the intensity of sprinting and relative rest was increased up to 110% of VTR.
Comparative group:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI between 27 and 35
排除标准
- •Diabetes (HbA1c>6,5%),
- •severe musculoskeletal (eg osteoarthritis),
- •cardiovascular (eg chronic heart failure) or respiratory (eg chronic obstructive pulmonary disease (COPD)) problems based on medical files.
结局指标
主要结局
Insulin sensitivity measured by oral glucose tolerance test
时间窗: Baseline and 10 weeks (end of intervention)
次要结局
- muscle fiber fat content measured by transmission electron microscopy in muscle biopsy(Baseline and 10 weeks (end of intervention))
- muscle fiber mitochondrial content measured by transmission electron microscopy in muscle biopsy(Baseline and 10 weeks (end of intervention))
- Respiratory exchange ratio measured by ergospirometry at rest(Baseline and 10 weeks (end of intervention))
- PeakVO2 measured by ergospirometry during maximal exercise testing(Baseline and 10 weeks (end of intervention))
- Ventilatory threshold measured by ergospirometry during maximal exercise testing(Baseline and 10 weeks (end of intervention))