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临床试验/NCT00004854
NCT00004854已完成1 期

The Safety and Efficacy of Adjunct Carvedilol in Children With Moderate Heart Failure

National Center for Research Resources (NCRR)2 个研究点 分布在 1 个国家开始时间: 2000年3月9日最近更新:
适应症
相关药物

试验速览

阶段
1 期
状态
已完成
发起方
试验地点
2

研究概览

简要总结

We would like to see if using Carvedilol in adjunct with Ace inhibitors will increase ejection fraction of the heart under echo. All interpretation of data will be sent to Boston Children's Hospital to be reviewed, which is the primary research center in this study. There are 5 hospitals participating in this study. The population targeted are children with moderate heart failure and must be on Ace inhibitors at the time of enrollment. Our outcome after placing them on Carvedilol is to change their ejection fraction on echo. The patients will be seen every 1-2 weeks, while we will titrate their medication to a maintenance dose. Secondary outcome is to increase quality of life, exercise tolerance and decrease their symptom scores as noted on their questionnaires.

研究设计

研究类型
Interventional
主要目的
Diagnostic

入排标准

年龄范围
3 Months 至 17 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Etiology of heart failure in Group 1 or Group 2
  • Moderate heart failure as evidenced by ventricular shortening fraction <= standard deviations below the mean, or ejection fraction <= 40% d) documented shortening fraction or ejection fraction that meet criteria for greater than 3 months
  • Standard medical therapy include ACE inhibitors plus or minus diuretics plus or minus digoxin; all efforts will made to maximize therapy prior to entry. Medication doses must be stable for 3 months prior to entry
  • Willingness to comply with followup testing

排除标准

  • 未提供

研究者

发起方
National Center for Research Resources (NCRR)
申办方类型
Nih

研究点 (2)

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