Verticality Perception - Multisensory Contribution

Not Applicable

Completed

• Conditions: Verticality Perception in Healthy Human Subjects; Individual Contribution of Different Sensory Systems
• Interventions: Other: Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk); Other: 3D-video-head impulse testing; Other: Vestibular-evoked myogenic potentials (VEMPs)

• Registration Number: NCT02212704
• Lead Sponsor: University of Zurich

Brief Summary

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-08-06
• Study First Submitted QC: 2014-08-07
• Study First Posted: 2014-08-08
• Study Start: 2014-10
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-29
• Last Update Posted: 2024-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• ages 18-60 years
• informed consent
• absence of exclusion criteria

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Exclusion Criteria

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Vestibular stimulation	Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk)	This is the experimental paradigm applied in all participants
Vestibular stimulation	3D-video-head impulse testing	This is the experimental paradigm applied in all participants
Vestibular stimulation	Vestibular-evoked myogenic potentials (VEMPs)	This is the experimental paradigm applied in all participants

Primary Outcome Measures

Name	Time	Method
Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions	During the turntable measurement (90 minutes)

Secondary Outcome Measures

Name	Time	Method
relative contribution of head- and trunk-based sensory systems based on Bayesian modelling	while on the turntable (1.5 hours)

Trial Locations

Locations (1)

University Hospital Zurich, Dept. of Neurology; 🇨🇭 Zurich, ZH, Switzerland