Verticality Perception - Multisensory Contribution

Not Applicable

Completed

• Conditions: Verticality Perception in Healthy Human Subjects; Individual Contribution of Different Sensory Systems

• Registration Number: NCT02212704
• Lead Sponsor: University of Zurich

Brief Summary

The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-08-06
• Study First Submitted QC: 2014-08-07
• Study First Posted: 2014-08-08
• Study Start: 2014-10
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-29
• Last Update Posted: 2024-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• ages 18-60 years
• informed consent
• absence of exclusion criteria

Exclusion Criteria

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions	During the turntable measurement (90 minutes)

Secondary Outcome Measures

Name	Time	Method
relative contribution of head- and trunk-based sensory systems based on Bayesian modelling	while on the turntable (1.5 hours)

Trial Locations

Locations (1)

University Hospital Zurich, Dept. of Neurology; 🇨🇭 Zurich, ZH, Switzerland