Verticality Perception - Dissociating Head and Trunk Contributors in Healthy Human Subjects
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Verticality Perception in Healthy Human Subjects
- Sponsor
- University of Zurich
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ages 18-60 years
- •informed consent
- •absence of exclusion criteria
Exclusion Criteria
- •peripheral-vestibular deficit
- •disturbed consciousness
- •history of sensory deficits
- •visual field deficits
- •other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •intake of antidepressants, sedatives, or neuroleptics
- •pregnancy, unless excluded by a negative pregnancy test
- •known neck pain or status post neck trauma
Outcomes
Primary Outcomes
Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions
Time Frame: During the turntable measurement (90 minutes)
Secondary Outcomes
- relative contribution of head- and trunk-based sensory systems based on Bayesian modelling(while on the turntable (1.5 hours))