Platelet reactivity and post-operative myocardial injury after major non-cardiac surgery (PROMISE).
- Conditions
- asymptomatic postoperative troponin elevationheart injury after surgeryMyocardial injury after noncardiac surgery10003184
- Registration Number
- NL-OMON47812
- Lead Sponsor
- Sint Antonius Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Patient must meet ALL of the following criteria:
* Males or females > 21 years of age and < 85 years
* Undergoing elective open abdominal vascular surgery
* On pre-operative ascal maintenance therapy
1) Patients who are unable to give informed consent or have life expectancy of < 1year
2) Subjects who have received thrombolytic therapy within 24 hours or GpIIb/IIIa-inhibitors within last 30 days
3) Subjects who had an acute coronary syndrome within the last 30 days
4) Subjects with a contra-indication to anticoagulation or at increased bleeding risk
a. Past or present history (<1 year) of bleeding from gastrointestinal (haematemesis) melena, frank bleed in stool or visible haematuria
b. Known platelet count (<100,00/mm3 ) or coagulopathy or platelet disorder
c. History of major recent (<30 day) surgery or trauma
5) Known Hb <6.5 mmol/L11g/dl or HCT <33%
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Peak postoperative cardiac troponin level</p><br>
- Secondary Outcome Measures
Name Time Method <p>Length of stay, myocardial infarction, stroke, death during hospital stay. </p><br>