Effect of Scalp Blocks on Postoperative Nausea & Vomiting & Recovery Profiles After Craniotomy: A Randomized, Double-Blind, and Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Nausea and Vomiting
- Sponsor
- Ain Shams University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- PONV incidence & severity during the 1st 24 hours in ICU.
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
In this study, the investigators hypothesize that preemptive scalp block in neurosurgical patients may decrease incidence of PONV after craniotomy through decreasing intraoperative inhalational agents' concentration and decreasing intraoperative opioids requirements, with better intraoperative hemodynamics and lesser recovery time
Detailed Description
Patients will be recruited after admission to the hospital for surgery. Randomization will be performed using computer-generated random number tables in opaque sealed envelopes prepared by an anesthesiologist who will be not part of the study Patients will be randomly divided into two groups using a computer generated random number chart. Group S received scalp block with 20 ml of 0.5% bupivacaine, whereas Group C received scalp block using 20 mL normal saline and will be considered as control group.
Investigators
Raham Hasan Mostafa, MD
Assistant Professor of Anesthesia
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •ASA I and II patients,
- •aged 18 to 50 years,
- •70-80 kg,
- •undergoing elective supratentorial craniotomy
Exclusion Criteria
- •patients under 18 years of age,
- •pregnancy,
- •emergency surgery,
- •patients with a Glasgow Coma Score (GCS) less than 15,
- •those with documented allergy to bupivacaine,
- •regular communication not possible,
- •Patients requiring prolonged mechanical ventilation (\> 2 hours after end of surgery) will be also excluded
Outcomes
Primary Outcomes
PONV incidence & severity during the 1st 24 hours in ICU.
Time Frame: 24 hours
The intensity of the PONV was classified as: 0: without PONV, 1: nausea, 2: vomiting and 3: vomiting more than 2 times \[8\]. In addition, the incidence of PONV, the first time there was need for ondansetron and its total dose was recorded. With PONV score ≥ 2, the investigators used 4 mg ondansetron IV for antiemetic regimen. The total dose over 24 hours (given as divided doses) must not exceed adult dose of 32 mg.
Secondary Outcomes
- Total intraoperative fentanyl consumption in microgram(6 hours)
- Recovery time in minutes(10 minutes)
- Intraoperative Mean blood pressure in mmHg(6 hours)
- Intraoperative Heart rate as number of beats per minute(6 hours)