Inhibitory effect of general anesthetics (remimazolam) on metabolism
Phase 2
- Conditions
- Surgical cases undergoing general anesthesia
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 14
Inclusion Criteria
Not provided
Exclusion Criteria
Patient factors: allergy to any of the components of remimazolam, history of central nervous system disease (cerebral infarction, cerebral hemorrhage, etc.), neuromuscular disease (myasthenia gravis, etc.), uncontrolled heart failure or respiratory failure, renal failure (serum creatinine > 2 mg/dl), liver failure (AST/ ALT > 2.5 ULN), and patients who do not consent to the study. ALT>2.5ULN), and those who do not consent to the study. Surgical factors: surgery requiring repositioning or isolated lung ventilation, head and neck surgery, emergency surgery
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compare oxygen consumption, carbon dioxide production, and total energy expenditure before and after induction of general anesthesia.
- Secondary Outcome Measures
Name Time Method Compare biological signs (blood pressure, heart rate, cardiac output, BIS) and oxygen supply/demand balance indices (CaO2, DO2, ERO2) before and after induction of general anesthesia. Comparison of drug effect site concentrations (remimazolam, remifentanil, fentanyl, volume of supplemental fluid, hypertensive drugs, etc.) after induction of general anesthesia. Compare the respiratory status of spontaneous breathing (volume and frequency of breathing) and ventilator settings during general anesthesia (volume and frequency of breathing, maximum airway pressure, compliance, and dead space volume). Factors contributing to the difference in EE before and after induction will be investigated by multivariate analysis.