Safety of Low PEEP Maneuvers During ARDS Management

Recruiting

• Conditions: Acute Respiratory Distress Syndrome; Positive End Expiratory Pressure

• Registration Number: NCT05922969
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown.

The aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-28
• Study First Submitted: 2023-06-20
• Study First Submitted QC: 2023-06-20
• Study First Posted: 2023-06-28
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-09
• Last Update Posted: 2024-07-10
• Primary Completion: 2024-11
• Study Completion: 2024-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• age : > 18 yo
• inclusion criteria: ARDS, Mechanical ventilation, low PEEP maneuvers

Exclusion Criteria

• refusal to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of oxygen desaturation	24 months

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France