Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS
- Conditions
- Ventilation Therapy; ComplicationsARDS, HumanAlveolar; Disorder
- Registration Number
- NCT05524558
- Lead Sponsor
- Bicetre Hospital
- Brief Summary
The corner stone of the treatment of ARDS is mechanical ventilation with high levels of positive end-expiratory pressure, also called PEEP. A high level of PEEP is recommended and frequently used. But PEEP can lower cardiac output and contribute to circulatory failure during mechanical ventilation. Nevertheless, in theory, the PEEP-induced pulmonary vascular resistance (PVR) increase could depend on the level of alveolar recruitment, but it has never been proven. Thus, the aim of this study is to determine the relation between the high-PEEP induced PVR and the alveolar recruitment or overdistension.
- Detailed Description
During acute respiratory distress syndrome (ARDS) the application of positive end-expiratory pressure (PEEP) prevents expiratory alveolar collapse. However, it can induce a predominant recruitment effect or, on the contrary, alveolar overdistension. The recruitment/overdistension ratio can be easily assessed using R/I ratio (or recruitment-to-inflation ratio). However, PEEP is likely to lower cardiac output and contribute to the cardiovascular failure that often occurs in patients with ARDS. Among its hemodynamic effects, PEEP is likely to increase pulmonary vascular resistance and, thus, right ventricular afterload. In theory, this effect should only occur if PEEP over-distends the lung volume, compressing the "extra-alveolar" vessels and increasing their resistance. However, this different effect of PEEP on pulmonary vascular resistance depending on the degree of recruitment or overdistension has never been demonstrated during ARDS in humans.
We retrospectively studied data collected from patients with ARDS, monitored by pulmonary artery catheter (PAC), to eventually find a correlation between the high PEEP-induced PVR increase and recruitement/overdistension profile.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 34
- ARDS diagnosed
- Invasive mechanical ventilation
- Pulmonary artery catheter already in place
- Esophagal pressure measure
- Pregnancy
- Prone position at inclusion
- Legal protection measures
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between PVR and recruitment-to-inflation ratio Up to hospital discharge (maximum : day 60) PVR collected at two levels of PEEP and the R/I ratio to assess a relationship between the two variables
- Secondary Outcome Measures
Name Time Method Relationship between the R/I ratio and blood gas analysis Up to hospital discharge (maximum : day 60) Data collected from the daily blood samples, to assess a relationship between R/I and arterial oxygen pressure
Relationship between the R/I ratio and respiratory system compliance Up to hospital discharge (maximum : day 60) Ventilatory parameters collected at two levels of PEEP and R/I collected every day to assess a correlation between R/I and lung compliance
Relationship between right ventricle size and R/I ratio Up to hospital discharge (maximum : day 60) Echocardiographic data collected at two levels of PEEP and R/I collected every day to assess a relationship between R/I and changes in RV surface.
Relationship between PVR change and Transpulmonary gradient (TPG) according to R/I Up to hospital discharge (maximum : day 60) Data collected from PAC and R/I measure every day to assess the relationship between R/I and TPG at two levels of PEEP.
Trial Locations
- Locations (1)
Bicetre Hospital
🇫🇷Le Kremlin-Bicêtre, Ile-de-France, France