PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT

Recruiting

• Conditions: ARDS; Respiratory Failure
• Interventions: Procedure: lung recruitment potential assessed by 3D EIT; Procedure: PEEP titration by 3D eit

• Registration Number: NCT06594601
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well as the extent of lung collapse and overdistension as detected by 3D-EIT.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2024-09
• Study First Submitted: 2024-09-02
• Study First Submitted QC: 2024-09-10
• Last Update Submitted: 2024-09-10
• Study First Posted: 2024-09-13
• Last Update Posted: 2024-09-13
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients on mechanical ventilation.
• Diagnosis of ARDS was based on the Berlin definition
• lung recruitment potential assessment and PEEP titration was proper for the ARDS patients determined by the attending doctor

Exclusion Criteria

• Under 18 years of age.
• Pregnant women;
• Ribcage malformation
• Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
• Hemodynamic instability, unable to tolerate high PEEP;
• High-risk individuals with pneumothorax, mediastinal emphysema, etc.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
lung recruitment potential assessed by 3D EIT in ARDS	lung recruitment potential assessed by 3D EIT	Diagnosis of ARDS was based on the Berlin definition, who have receivied mechanical ventilation. The enrolled patients received a lung recruitment potential assessment by 3D EIT( as the follwoing mentioned )
PEEP titration by 3D EIT for ARDS	PEEP titration by 3D eit	Diagnosis of ARDS was based on the Berlin definition, who have receivied mechanical ventilation. The enrolled patients received a lung PEEP tirtation by 3D EIT( as the follwoing mentioned )

Primary Outcome Measures

Name	Time	Method
OD/CL and optimal PEEP monitored by EIT	5-10min	Monitoring the lung collapse and overdistension region by EIT at different PEEP levels. Measure the optimal PEEP level based on collapse and overdistension rate.

Secondary Outcome Measures

Name	Time	Method
ventilation distribution monitored by EIT	5-10min	Monitoring the lung ventilation distribution by EIT at different PEEP levels
GI monitored by EIT	5-10min	Global Inhomogeneity (GI) Index monitored by EIT at different PEEP levels
CoV monitored by EIT	5-10min	Center of ventilation (COV) monitored by EIT at different PEEP levels
V/Q monitored by EIT	5-10min	Ventilation and perfusion monitored by EIT at different PEEP levels. To evaluate the V/Q match, deadspace and shunt lung region.

Trial Locations

Locations (1)

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,; 🇨🇳 Beijing, Beijing, China