The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

Not Applicable

Completed

• Conditions: Lipid Profile
• Interventions: Dietary Supplement: The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

• Registration Number: NCT01124487
• Lead Sponsor: Malaysia Palm Oil Board

Brief Summary

Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.

Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.

Detailed Description

A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(\<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.

Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers

Study Timeline

• Study Start: 2009-08
• Primary Completion: 2009-09
• Study Completion: 2009-09
• Status Verified: 2010-05
• Study First Submitted: 2010-05-12
• Study First Submitted QC: 2010-05-14
• Last Update Submitted: 2010-05-14
• Study First Posted: 2010-05-17
• Last Update Posted: 2010-05-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Age: 18-45 years
• BMI : 18.5-30 kg/m^2
• Healthy, men

Exclusion Criteria

• medical history of cardiovascular disease, cancer, diabetes or chronic diseases
• BMI < 18.5 OR > 30 kg/m^2
• waist hip ratio > 0.9
• total cholesterol > 5.2 mmol/L
• triacylglycerol (TAG) > 2.2 mmol/L
• current use of antihypertensive or lipid lowering medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
palm olein	The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers	-
olive oil	The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers	-
lard	The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers	-

Primary Outcome Measures

Name	Time	Method
Triacylglycerol (TAG)	4 h

Secondary Outcome Measures

Name	Time	Method
Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers	4 h

Trial Locations

Locations (1)

Malaysian Palm Oil Board; 🇲🇾 Kajang, Selangor, Malaysia