Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile

Not Applicable

Completed

• Conditions: Healthy Nutrition; Diet, Healthy
• Interventions: Dietary Supplement: Lipidomics

• Registration Number: NCT06368271
• Lead Sponsor: University of Copenhagen

Brief Summary

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

Detailed Description

Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days.

On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.

Study Timeline

• Study Start: 2021-10-01
• Primary Completion: 2024-02-28
• Study Completion: 2024-02-28
• Status Verified: 2024-04
• Study First Submitted: 2024-04-05
• Study First Submitted QC: 2024-04-10
• Last Update Submitted: 2024-04-10
• Study First Posted: 2024-04-16
• Last Update Posted: 2024-04-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 4

Inclusion Criteria

healthy males BMI:20-27 recreationally physical active non-smoker no medicine

Exclusion Criteria

• high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intake of fatty acids	Lipidomics	,Participants ingest a test drink containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk) within five min. Blood and oxygen uptake are obtained frequently during the following 4 hours.

Primary Outcome Measures

Name	Time	Method
Meal test including medium-chain fatty acids	0-4 hours	In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men. Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile

Secondary Outcome Measures

Name	Time	Method
Resting metabolic rate	0-4 hours	The secondary outcome of this study is to investigate the effect of an acute intake of MCT or LCT oil (35g of MCT or LCT) on resting metabolic rate in healthy lean men

Trial Locations

Locations (2)

University of Copenhagen; 🇩🇰 Copenhagen, Denmark

Department of Nutrition, Exercise and Sports; 🇩🇰 Copenhagen, Denmark