The anti-erosion effects of two different toothpastes on tooth enamel

Not Applicable

Completed

• Conditions: Enamel erosion; Oral Health

• Registration Number: ISRCTN55245733
• Lead Sponsor: The Procter and Gamble Company

Brief Summary

2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29630787 results 2018 Results article in https://pubmed.ncbi.nlm.nih.gov/30556372/ erosion protection efficacy (added 08/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04-15
• Study Completion: 2015-06-30
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1. Provide written informed consent to participate in the study, and receive a copy of the signed consent form
2. Agree not to participate in any other oral/dental product studies during the course of the study
3. Agree to delay any elective dentistry (including dental prophylaxis) until the study has been completed
4. Agree to refrain from the use of any non-study dentifrice or other oral hygiene products for the duration of the study
5. Agree to return for all scheduled visits and follow study procedures
6. 18 years and older
7. Agree to refrain from taking an acidic medication (pH <5.3) during the course of the study
8. Be in good general health, as determined by the Investigator/designee based on a review of the health history/update for participation in the study

Exclusion Criteria

1. Susceptibility to acid regurgitation
2. Recurrent or regular aphthous ulcers
3. Dental erosion or a previous history of being susceptible to high dental erosion after drinking sports drinks or juices
4. Excessive gingival inflammation
5. Severe periodontal disease, as characterized by purulent exudate, generalized mobility, and/or severe recession
6. Any pre-existing oral or medical condition that the examiner determines may place the subject at increased health risk from study participation
7. Non-removable mouth or tongue jewellery
8. Any subject who in the opinion of the investigator (or medically qualified designee) should not participate in the study
9. Personnel, i.e. an employee of the Sponsor, member of the Clinical Trials Unit at the Bristol Dental School and Hospital or family relative. Employees of the Bristol Dental School and Hospital or Bristol University not associated with the Clinical Trials Unit are eligible to participate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dental erosion measured by profilometry at baseline and Day 10

Secondary Outcome Measures

Name	Time	Method
There are no secondary outcome measures