Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis
- Conditions
- Rheumatoid Arthritis
- Registration Number
- NCT01111357
- Lead Sponsor
- University Hospital Center of Martinique
- Brief Summary
Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Diagnosis of Rheumatoid Arthritis according to ACR criteria
- Come from French West Indies (At least 3 grandparents are African-Caribbean)
- Sign written informed consent
- Minor
- Patient with no Rheumatoid Arthritis according to ACR criteria
- Patient does not agree for a genetic study
For the control
Inclusion Criteria:
- Blood donor
- Sign written informed consent
- Patient with no Rheumatoid Arthritis according to ACR criteria
- Come from French West Indies (At least 3 grandparents are African-Caribbean)
Exclusion Criteria:
- Minor
- Patient does not agree for a genetic study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference of distribution of HLA alleles in patients and in healthy controls 1 day
- Secondary Outcome Measures
Name Time Method The association between the different HLA alleles among French West-Indian RA patients and the autoantibodies production. 1 day The association between the different HLA alleles among French West-Indian RA patients and the radiological damage. 1 day The association between the different HLA alleles among French West-Indian RA patients and the response to therapy 1 day
Trial Locations
- Locations (1)
Service de rhumatologie CHU de Fort-de-France
🇲🇶Fort-de-France, Martinique
Service de rhumatologie CHU de Fort-de-France🇲🇶Fort-de-France, Martinique