NCT01111357已完成不适用
Study of HLA Polymorphisms in French West-Indian Patients With Rheumatoid Arthritis : A Case Control Study
University Hospital Center of Martinique1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2010年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Difference of distribution of HLA alleles in patients and in healthy controls
研究概览
简要总结
Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Rheumatoid Arthritis according to ACR criteria
- •Come from French West Indies (At least 3 grandparents are African-Caribbean)
- •Sign written informed consent
排除标准
- •Patient with no Rheumatoid Arthritis according to ACR criteria
- •Patient does not agree for a genetic study
- •For the control
- •Inclusion Criteria:
- •Blood donor
- •Sign written informed consent
- •Patient with no Rheumatoid Arthritis according to ACR criteria
- •Come from French West Indies (At least 3 grandparents are African-Caribbean)
- •Exclusion Criteria:
- •Patient does not agree for a genetic study
结局指标
主要结局
Difference of distribution of HLA alleles in patients and in healthy controls
时间窗: 1 day
次要结局
- The association between the different HLA alleles among French West-Indian RA patients and the autoantibodies production.(1 day)
- The association between the different HLA alleles among French West-Indian RA patients and the radiological damage.(1 day)
- The association between the different HLA alleles among French West-Indian RA patients and the response to therapy(1 day)
研究者
研究点 (1)
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