Oxygen therapy in pneumonia

Phase 4

Recruiting

• Conditions: Pneumonia; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12607000196448
• Lead Sponsor: Medical Research Institute of New Zealand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-04-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

CoughAt least one systemic feature (sweating, rigors and/or fever >37.8 C)Respiratory rate >18 breaths/min.

Exclusion Criteria

Respiratory failure requiring mechanical ventilation; Diagnosis of Chronic Obstructive Pulmonary Disease (COPD)/emphysema; Acute electrocardiogram (ECG) changes suggesting ischaemia; Suspected neutropenic sepsis; Known or suspected chronic hypercapnic respiratory failure as a result of any of the following disorders - neuromuscular disease, chest wall disease, obesity hypoventilation syndrome.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of patients with an increase in partial pressure of arterial carbon dioxide (PaCO2) greater than or equal to 4mmHg[At 1 hour]

Secondary Outcome Measures

Name	Time	Method
Proportion of patients with a partial pressure of arterial carbon dioxide (PaCO2) greater than or equal to 38mmHg and an increase of greater than or equal to 4mmHg.[At 1 hour];Change in respiratory rate and heart rate at time 0, 20minutes, 40minutes and 1hour.[At time 0, 20minutes, 40minutes and 1hour];Need for hospital admission at the end of the emergency department treatment period. The end of the emergency department treatment is variable as it depends on the patient and the severity of the condition, and therefore a time can not be specified.[The end of the emergency department treatment is variable as it depends on the patient and the severity of the condition, and therefore a time can not be specified.];Mean change in PaCO2.[At time = 1 hour];Combined primary endpoint with oxygen and asthma study ACTRN012607000131459 measured as the total proportion of patients in the asthma and pneumonia trials with an increase in PaCO2 greater than or equal to 4mmHg at time=1 hour[Time = 1 hour]