Mucosal immunity in patients diagnosed with SARS-CoV-2 infection and their household contacts

Completed

• Conditions: coronavirus; 10047438; COVID-19

• Registration Number: NL-OMON49964
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patient with a laboratory-confirmed SARS-CoV-2 infection in home isolation with
at least two household contacts remaining in home quarantine at the same
address.

Exclusion Criteria

Patients with a negative indication for home isolation

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This is an exploratory study in which the primary aim is to study the<br /><br>development of antibodies to SARS-CoV-2 in nasal fluid of COVID-19 patients and<br /><br>their household contacts.<br /><br><br /><br>Primary outcome:<br /><br>- Descriptive analysis of SARS-CoV-2 IgG and IgGA concentrations in nasal fluid<br /><br>at the various time points. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Detection of SARS-CoV-2 in diagnostic specimen<br /><br>- Descriptive analysis of inflammatory markers in nasal fluid<br /><br>- Descriptive analysis of correlation of antibodies with viral diagnostics and<br /><br>disease symptoms</p><br>