NCT04160832
Completed
Not Applicable
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients with Advanced Colorectal Polyps
ConditionsColorectal Neoplasm
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colorectal Neoplasm
- Sponsor
- University of Colorado, Denver
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Prevalence of germline pathogenic/likely pathogenic variants in cancer predisposition genes in patients with advanced colorectal polyps
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The study is being conducted to determine the prevalence and risk factors for germline cancer susceptibility genetic mutations among patients with advanced colorectal polyps.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Provision to sign and date the consent form
- •Stated willingness to comply with all study procedures and be available for the duration of the study
- •Be a male or female aged 18-89
- •Undergone colonoscopy
- •At least one advanced colorectal polyp, defined as having any of the following:
- •Any polyp ≥ 1cm (adenoma or serrated polyp)
- •Any polyp with villous architecture
- •Any polyp with high-grade dysplasia
- •Sessile serrated polyps with any dysplasia
- •Traditional serrated adenoma
Exclusion Criteria
- •Known hereditary cancer syndrome
- •Personal history of inflammatory bowel disease
- •Personal history of colorectal cancer
- •Polyp histology or size unavailable or not documented
Outcomes
Primary Outcomes
Prevalence of germline pathogenic/likely pathogenic variants in cancer predisposition genes in patients with advanced colorectal polyps
Time Frame: 3 years
Secondary Outcomes
- Risk factors for germline pathogenic/likely pathogenic variants in patients with advanced colorectal polyps(3 years)
Study Sites (1)
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