NCT04160832已完成不适用
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients with Advanced Colorectal Polyps
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Prevalence of germline pathogenic/likely pathogenic variants in cancer predisposition genes in patients with advanced colorectal polyps
研究概览
简要总结
The study is being conducted to determine the prevalence and risk factors for germline cancer susceptibility genetic mutations among patients with advanced colorectal polyps.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Provision to sign and date the consent form
- •Stated willingness to comply with all study procedures and be available for the duration of the study
- •Be a male or female aged 18-89
- •Undergone colonoscopy
- •At least one advanced colorectal polyp, defined as having any of the following:
- •Any polyp ≥ 1cm (adenoma or serrated polyp)
- •Any polyp with villous architecture
- •Any polyp with high-grade dysplasia
- •Sessile serrated polyps with any dysplasia
- •Traditional serrated adenoma
排除标准
- •Known hereditary cancer syndrome
- •Personal history of inflammatory bowel disease
- •Personal history of colorectal cancer
- •Polyp histology or size unavailable or not documented
结局指标
主要结局
Prevalence of germline pathogenic/likely pathogenic variants in cancer predisposition genes in patients with advanced colorectal polyps
时间窗: 3 years
次要结局
- Risk factors for germline pathogenic/likely pathogenic variants in patients with advanced colorectal polyps(3 years)
研究者
研究点 (1)
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