Urinary CXCL10 Pilot Implementation Trial
- Conditions
- Kidney Transplant Rejection
- Registration Number
- NCT06564649
- Lead Sponsor
- University of British Columbia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not yet recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria:<br><br> - Prevalent pediatric kidney transplant recipients (<19 years at transplantation) who<br> are more than 6 months after transplant, with informed consent and assent.<br><br> - Must be available to follow-up for two years after initiation of urinary CXCL10<br> monitoring<br><br>Exclusion Criteria:<br><br> - Expected transfer to adult care in the next 2 years.<br><br> - In center routine follow-up interval >3 months between visits<br><br> - Non-adherence to routine transplant clinic visits.<br><br> - Recent acute rejection episode in the last 3 months prior to enrolment. Patients may<br> be enrolled if rejection was more than 3 months prior to enrolment. No exclusion for<br> donor-specific antibody in the absence of acute cellular or antibody-mediated<br> rejection.<br><br> - Estimated glomerular filtration rate <30 ml/min/1.73m2 (stage IV/V CKD).<br><br> - Inability to reliably obtain urinary samples for monitoring purposes.<br><br> - Contraindication to kidney biopsy.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Capacity of Recruitment for future definitive trial
- Secondary Outcome Measures
Name Time Method Study Protocol Feasibility;Trial Cost and logistical support evaluation