A novel ultrasound method for heart failure detectio

Not Applicable

• Conditions: Heart failure or those with left ventricular diastolic dysfunction but without clinical symptoms or signs of heart failure; Circulatory System

• Registration Number: ISRCTN17117016
• Lead Sponsor: Imperial College Healthcare NHS Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-25
• Last Update Posted: 7 August 2023
• Study Completion: 2024-08-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

Healthy volunteers:
1. Members of staff who are clinically well

Patients:
1. Patients with heart failure and left ventricular systolic impairment (ejection fraction, measured by biplane Simpsons methodology on echocardiography, <40%)
2. Patients with heart failure and preserved left ventricular systolic function (ejection fraction >50%)
3. Patients without clinical symptoms or signs of heart failure but with left ventricular diastolic dysfunction with an E/E’ ratio of 15+

Exclusion Criteria

1. Known arrhythmias
2. Hypertension (except for the hypertensive control group)
3. Hyperlipidemia
4. Aneurysm
5. Diabetes
6. Heart failure
7. Taking medication for cardiovascular conditions
8. Lack capacity to consent

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
At a single time point:<br>1. Wave intensity metrics obtained from non-invasive ultrasound measurements taken from the carotid, brachial and radial arteries using a range of ultrasound scanners (At present, a research ultrafast scanner is used.) <br>2. Routinely collected transthoracic echocardiography data using patient records.

Secondary Outcome Measures

Name	Time	Method
There are no secondary outcome measures