Protective Effects of Bisoprolol against Acute Exacerbation in Moderate-to-Severe Chronic Obstructive Pulmonary Disease
- Conditions
- chronic obstructive pulmonary disease, hypertension
- Registration Number
- JPRN-UMIN000024712
- Lead Sponsor
- Okayama University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 35
Not provided
(1) patients with severe (NYHA grade 3 or 4) cardiac failure (2) left ventricular contractility of 40% or less (3) 2nd/3rd-degree atrioventricular block, sinoatrial block or sick sinus syndrome (4) variant angina pectoris (5) severe peripheral circulatory disturbance (6) pulmonary hypertension from right cardiac failure (7) a history of pulmonary resection (8) malignancy of disease-free interval of less than 3 years (9) systolic blood pressure of less than 100 mmHg (10) cardiac rate of less than 60 bpm on a constant basis (11) uncontrolled diabetic mellitus (12) thyrotoxicosis (13) pheochromocytoma (14) psoriasis (15) use of supplemental oxygen or with SpO2 of less than 90%(or PaO2 of less than 60 Torr) (16) asthma (17) active interstitial pneumonia (18) COPD exacerbation or respiratory infection within 4 weeks before registration (19) pregnant women (20) current use of beta-blocker (21) history of hypersensitivity to bisoprolol (22) patients considered to be inappropriate for this study by attending physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method