Effect of Short-term Bisoprolol on Perioperative Myocardial Injury in Patient Undergoing Non-cardiac Surgery
- Conditions
- The patient who undergo abdominal aortic surgeryThe patient who undergo infrainguinal arterial reconstruction surgeryThe patient who undergo non-cardiac thoracic surgeryBisoprololPerioperative Myocardial InjuryNon-cardiac Surgery
- Registration Number
- TCTR20180329005
- Lead Sponsor
- The Thailand Research Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 116
The study will include all patients, aged more than 45 year, who
are postmenopausal or are using a reliable means of contraception
and undergo major elective abdominal aortic or infrainguinal arterial
reconstruction surgery or non-cardiac thoracic surgery under general
anesthesia at Maharaj Nakorn Chiang Mai hospital.
• Patients will be excluded if they meet any of the following criteria:
1. Already taking beta-blockers
2. Giving beta-blockers will be dangerous (e.g., known intolerance to
beta-blockers)
3. Receiving current treatment for asthma/COPD
4. Presence of bradycardia (heart rate < 60 bpm) or hypotension
(systolic blood pressure <100 mm Hg)
5. Plan to use a beta †blocker preoperatively or during the first 30
postoperative days for other reason
6. Concurrent use of verapamil, diltiazem or amiodarone
7. Urgent / emergency vascular surgery within 24 hr
8. Have had CABG with complete revascularization in 5 years & no
evidence of ischemia since surgery
9. Active cardiac condition
10. Not give informed consent
11. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of perioperative myocardial injury Day 1, Day 2 and day 3 Troponin T level
- Secondary Outcome Measures
Name Time Method Incidence of cardiovascular event 30 day cardiovascular death, nonfatal MI and nonfatal stroke until 30 days after surgery