The Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Presenting to the Emergency Department With Acute Coronary Syndrome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 238
- Primary Endpoint
- serum netrin-1 value
Study Overview
Brief Summary
In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher Netrin-1 levels.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- Single (Participant)
Masking Description
Patient group; Those diagnosed with ACS over 18 years of age, planned angiography and accepted angiography. The control group consisted of volunteers without disease.
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients over the age of 18
- •diagnose ACS
- •patients undergoing angiography
Exclusion Criteria
- •CVE history
- •Neurological disease
- •Pregnancy and Lactation
- •Liver failure
- •Diagnosed malignity
- •Use of anticonvulsant and nephrotoxic medication
- •Chronic kidney disease
- •Not having angiography
- •Developing acute renal failure after angiography
- •Patients who rejected to participate were excluded.
Outcomes
Primary Outcomes
serum netrin-1 value
Time Frame: 30 minute
Netrin-1 in plasma was measured by enzyme-linked immunosorbent assay (ELISA) (Mybıosource MBS044526 ) All assays were performed in duplicate. Plasma Netrin-1 is expressed in picograms (pg) per mg.
Secondary Outcomes
No secondary outcomes reported
Investigators
huseyin mutlu
Asst. Prof. Dr. Principal Investigator
Aksaray University Training and Research Hospital