To see the effect of 2 medicines namely panchasama churna and kshara basti in the treatment of disease Amavata(Rheumatoid Arthritis)Â

Phase 2

Conditions: Health Condition 1: M05- Rheumatoid arthritis with rheumatoid factor

Registration Number: CTRI/2022/04/042053

Lead Sponsor: Ayurvedic and Unani Tibbia College Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1 Patient willing to participate in the trial.

2 The patients between the age group of 18 to 60 years.

3 Patients having classical features of Amavata like Angamarda(malaise), Aruchi(Anorexia), Trishna(excessive thirst), Alasya(laziness), Gaurava(heaviness of body), Jwara(fever), Apaka(indigestion), Angashoonata(swelling).

4 Pt. who is taking anti inflammatory(analgesics) will be included after a washout period of 7days provided they are diagnosed with RA in last 1 year.

5 The patients should fulfil the 2010 ACR(American College of Rheumatology) EULAR (European League Against Rheumatism) criteria for rheumatoid arthritis.

Exclusion Criteria

1 Patients having Severe crippling bone deformity.

2 Pt. who are on DMRDs and Biologicals are not included in study.

3 Patients having another type of arthropathy such as Neoplasm of spine, Gout, Ankylosing spondylitis etc.

4 Patients having associated Cardiac disease, Pulmonary Tuberculosis.

5 Patients with genetic and endocrinal disorder, chronic disorder like Paralysis, Cancer, Renal failure, Hepatic failure.

6 H/O of hypersensitivity of any trial drug.

Patients taking antibiotic therapy for any systemic illness within 2 months.

7 Pregnant women and lactating mother.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1 The assessment of effect of Panchsama churna on the cardinal features <br/ ><br>2 The assessment of effect of Ksharbasti karma <br/ ><br>3 The assessment of effect of Ksharbasti karma along with Panchsama churna <br/ ><br>4 Improvement in subjective parameters like <br/ ><br>1 Pain in joints <br/ ><br>2 swelling in joints <br/ ><br>3 Tenderness of joints <br/ ><br>4 Stiffness of jointsTimepoint: At baseline and after 12 weeks

Secondary Outcome Measures

Name	Time	Method
Assessment will be done clinically on basis of improvement in objective parameters like RA Factor, CRP, ESR and Anti-CCP.Timepoint: At baseline and after 12 weeks