Comparison of the Incidence of Delirium Caused by Different Anesthetic Agents in Patients Undergoing Liver Transplantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hepatocellular Carcinoma
- Sponsor
- Yonsei University
- Enrollment
- 350
- Locations
- 1
- Primary Endpoint
- incidence of postoperative delirium
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This study is a prospective observational study that analyzes the incidence of postoperative delirium in patients undergoing liver transplantation, based on the use of the inhalational anesthetic sevoflurane and the intravenous anesthetic propofol.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults aged 19 years and older
- •Patients undergoing liver transplantation who are scheduled to receive anesthesia with the inhaled anesthetic sevoflurane or the intravenous anesthetic propofol.
Exclusion Criteria
- •Individuals with hearing loss, cognitive impairment or obvious dementia, hepatic encephalopathy, or difficulty in communication.
- •Diagnosed with neurological disorders (e.g., brain hemorrhage, stroke, dementia, Parkinson's disease, cognitive impairment, etc.).
Outcomes
Primary Outcomes
incidence of postoperative delirium
Time Frame: from postoperative day 0 to postoperative day 7
At least two times a day during the hospitalization period. Patients diagnosed with delirium using the CAM were evaluated for the duration, symptoms, and type of delirium (e.g., reduced awareness of the environment; poor cognitive skills; behavioral changes; and emotional disturbances). \*\* Confusion assessment methods(CAM) diagnostic algorism (positive or negative result, positive means delirium) CAM is considered positive if features 1 and 2 are present, with at least one of features 3 or 4. Below are the four criteria of features : 1. Acute onset and fluctuating course Determined by collateral history or repeated clinic assessment 2. Inattention Counting from 20-1 is a simple (if blunt) test for this 3. Disorganized thinking 4. Altered levels of consciousness
Secondary Outcomes
- comprehensive geriatric assessment(CGA)(Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks)
- duration of delirium(Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks)
- total score of QOR-40(Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks)
- type of delirium(Participants will be followed for the duration of their hospital stay and until their visit within one month after discharge, with an expected average of 4 weeks)