Study of LJP 394 in Lupus Patients With History of Renal Disease
- Conditions
- Lupus Erythematosus, SystemicLupus Nephritis
- Interventions
- Drug: abetimus sodium (LJP 394) and/or placebo solutionDrug: abetimus sodium (LJP 394)Drug: Phosphate-buffered saline
- Registration Number
- NCT00089804
- Lead Sponsor
- La Jolla Pharmaceutical Company
- Brief Summary
The primary purpose of this study is to determine whether abetimus sodium is more effective than placebo in delaying time to renal flare in SLE patients with a history of renal disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 943
- Diagnosis of Systemic Lupus Erythematosus (SLE)
- Active SLE renal disease within past 4 years.
- Males or females between 12 and 70 years old.
- Females must be non-pregnant and non-lactating. Females and males must use adequate birth control methods during course of study.
- Ability to have weekly intravenous (IV) administration of study treatment.
- Active SLE renal disease within past 3 months prior to entering study.
- Use of the following therapies within 3 months prior to entering the study: alkylating agents, e.g., cyclophosphamide, TNF inhibitors, cyclosporine.
- Use of mycophenolate mofetil that exceeds 1000 mg/day, azathioprine that exceeds 100 mg/day, methotrexate that exceeds 10 mg/week, leflunomide that exceeds 10 mg/day within 2 months prior to entering study.
- Use of rituximab within 6 months prior to entering study.
- Current abuse of drugs or alcohol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 abetimus sodium (LJP 394) and/or placebo solution 300 mg (three 2 mL vials of abetimus sodium plus six 2 mL vials of normal saline) administered i.v (in the vien) weekly 2 abetimus sodium (LJP 394) 900 mg (nine 2 mL vials of abetimus sodium) administered i.v. (in the vein) weekly 3 Phosphate-buffered saline A volume of 18 mL (Nine 2 mL vials) of identically appearing placebo (phosphate-buffered saline) administered i.v. (in the vien) weekly
- Primary Outcome Measures
Name Time Method To determine whether abetimus sodium is more effective than placebo in delaying the time to renal flare in SLE patients with a history of SLE renal disease. Weekly administration with a 52-week treatment duration. Time to event (12 months fixed treatment duration)
- Secondary Outcome Measures
Name Time Method To determine whether treatment with abetimus sodium is more effective than placebo in delaying the time to Major SLE flare; and to determine whether treatment with abetimus sodium (LJP 394) is more effective than placebo in reducing proteinuria. 12 month fixed treatment duration
Trial Locations
- Locations (198)
Ohio State University Medical Center
🇺🇸Columbus, Ohio, United States
Miami Children's Hospital
🇺🇸Miami, Florida, United States
CRIA Research
🇺🇸Fort Lauderdale, Florida, United States
Debrecen Medical University
🇭🇺Debrecen, Hungary
Ochsner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
CIR Hospital Sirio Libanes. Campana 4658
🇦🇷Buenos Aires, Ciudad Autonma de, Argentina
Minsk City Clinical Hospital # 2
🇧🇾Minsk, Belarus
Hospital Universitario Pedro Ernesto
🇧🇷Rio de Janeiro, Avenida 28 de Setembro, 77, Brazil
Rua Pedro de Toledo 1800 9 andar/ Ala central - Diretoria de Servico de Reumatologia
🇧🇷Săo Paulo - SP, Brazil
NMTranspH "Tsar Boris Treti", Clinic of Internal Diseases
🇧🇬Sofia, 104 "Maria Louisa" blvd., Bulgaria
MHAT "Stara Zagora", Second Clinic of Internal Diseases
🇧🇬Stara Zagora, 11 "Armeiska" street, Bulgaria
Military Medical Academy, Clinic of Urology and Nephrology
🇧🇬Sofia, 3, Georgi Sofiiski, str., Bulgaria
Clinic of Nephrology, MHAT "Alexandrovska" 1, Georgi Sofiiski, str.,
🇧🇬Sofia, Bulgaria
Academic VL Tsitlanadze Scientific - Practical Center of Rheumatology
🇬🇪Tbilisi, Georgia
Georg August Universität Göttingen Universitätsklinikum, Zentrum Innere Medizin
🇩🇪Göttingen, Robert-Kochstr. 40, Germany
Johannes Gutenberg-Universität I. Medizinische Klinik und Poliklinik,Langenbeckstr. 1
🇩🇪Mainz, Germany
The Chinese University of Hong Kong, Prince of Wales Hospital
🇭🇰Hong Kong, Hong Kong
Szent Margit Hospital, Department of Nephrology
🇭🇺Budapest, Hungary
Diagnostic Units Hungary Kft.
🇭🇺Budapest, Hungary
Szent László Kórház, VI. Fertőző Belosztály
🇭🇺Budapest, Hungary
Petz Aladar Megyei Oktato Korhaz, Immunnephrologia es Hypertonia Osztaly
🇭🇺Gyor, Hungary
Global Hospitals
🇮🇳Hyderabaad, Andhra Pradesh, India
PVS Memorial Hospital Ltd.
🇮🇳Cochin, Kaloor, Kerala, India
Apollo Gleneagles Hospital
🇮🇳Kolkatta, Kankurgachi, India
M.P. Shah Medical College & G.G. Hospital
🇮🇳Jamnagar, Gujarat, India
St. Johns Medical College and Hospital, Dept. of Nephrology
🇮🇳Bangalore, Karnataka, India
M.S. Ramaiah Memorial Hospital
🇮🇳Bangalore, Karnataka, India
Amrita Institute of Medical Sciences
🇮🇳Kochin, Kerala, India
Consultant and Head Department of Nephrology, Kamineni Hospitals
🇮🇳Hyderabaad, L.B. Nagar, India
Post Graduate Institute of Medical Education and Research
🇮🇳Chandigarh, India
Devaki Hospital Ltd., Dept. of Nephrology
🇮🇳Chennai, India
Madras Institute of Nephrology, Vijaya Health Center
🇮🇳Chennai, India
Fortis Hospital, Dept. of Nephrology & Hypertension
🇮🇳Noida, Uttar Pradesh, India
Spectra Apollo Research Foundation
🇮🇳Chennai, India
Medwin Hospital
🇮🇳Hyderabaad, India
Nizams Institute of Medical Sciences
🇮🇳Hyderabaad, India
Department of Nephrology, CARE Hospital, Banjara Hills
🇮🇳Hyderabad, India
Armenian Church Trauma Center - Unit of Rabindranath Tagore International Institute of Cardiac Sciences
🇮🇳Kolkata, India
P.D. Hinduja National Hospital and Research Center
🇮🇳Mumbai, India
Sanjay Ghandi Post Graduate Institute of Medical Sciences
🇮🇳Lucknow, India
BYL Nair Charitable Hospital & TN Medical College
🇮🇳Mumbai, India
Department of Nephrology, JSS Hospital, Ramanuja Road
🇮🇳Mysore, India
Indraprastha Apollo Hospital
🇮🇳New Delhi, India
Jehangir Hospital, 32 Sassoon Road
🇮🇳Pune, India
Medical College Trivandrum
🇮🇳Trivandrum, India
King George Hospital
🇮🇳Visakhapatnam, India
RS Kramat 128
🇮🇩Jakarta, Jl. Kramat Raya, Pusat, Indonesia
RS Hasan Sadikin
🇮🇩Bandung, Jl. Pasir Kaliki No. 190, Jawa Barat, Indonesia
Arcispedale S. Anna, Divisione di Reumatologia
🇮🇹Ferrara, Corso Giovecca 203, Italy
Azienda Ospedaliera Cattedra di Reumatologia
🇮🇹Padova, Via Giustiniani, 2, Italy
Universita di Pisa, Dipartimento di Medicina Interna
🇮🇹Pisa, Via Roma 67, Italy
Ewha Woman's University College of Medicine, Mockdong Hospital
🇰🇷Seoul, Yangcheon-Gu, Korea, Republic of
Bundang Cha General Hospital, Pochon Cha University
🇰🇷Kyonggi-do, Korea, Republic of
Pusan National University Hospital
🇰🇷Pusan, Korea, Republic of
Seoul National University Hospital, Department of Internal Medicine
🇰🇷Seoul, Korea, Republic of
The Hospital for Rheumatic Disease, Hanyang University Medical Center
🇰🇷Seoul, Korea, Republic of
Kangnam St. Mary's Hospital, Catholic University of Korea
🇰🇷Seoul, Korea, Republic of
Albert Haykel Hospital
🇱🇧Haykaliyeh-Tripoli, Lebanon
St. Mary's Hospital, Catholic University of Korea
🇰🇷Seoul, Korea, Republic of
Nabatieh Governmental Hospital
🇱🇧Nabatieh, Lebanon
Hammoud Hospital University Medical Center
🇱🇧Saida, Lebanon
Labib Medical Center
🇱🇧Saida, Lebanon
CAPD Unit, Queen Elizabeth Hospital,
🇲🇾Sabah, Kota Kinabalu, Malaysia
Department of Medicine, Hospital Pulau Pinang,
🇲🇾Pulau Pinang, Jalan Residensi, Malaysia
Department of Medicine, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce,
🇲🇾Sarawak, Kuching, Malaysia
Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Departmento de inmunologia y Reumatologia
🇲🇽Delagacion Tlalpan, D.f., Mexico
Clínica de Diagnóstico y Tratamiento de las Enfermedades Reumáticas
🇲🇽Mexico City, D.f., Mexico
Blvd. Sanchez Taboada 9250-28 - Private Practice
🇲🇽Tijuana, Baja California, Mexico
Colomos #2292, Col. Providencia
🇲🇽Guadalajara, Jalisco, Mexico
Centro de Estudios de Investigación Básica y Clínica S.C.
🇲🇽Guadalajara, Jalisco, Mexico
Poliplaza Medica
🇲🇽Chihuahua, Mexico
Reumatologia
🇲🇽Mexicali, Mexico
Chung Hua Hospital
🇵🇭Cebu, Philippines
Hospital Privado San José de Ciudad Obregón, S.A. de C.V. Coahuila No. 263 Sur. Col. Centro. Ciudad Obregón
🇲🇽Sonora, Mexico
Davao Doctors Hospital
🇵🇭Davao, Philippines
Philippine General Hospital
🇵🇭Manila, Philippines
Joint and Bone Center, University of Santo Tomas Hospital
🇵🇭Manila, Philippines
Klinika Medycyny, Transplantacyjnej i Nefrologii in Warszawa, Nowogrodzka 59, At SPZOZ Szpital Kliniczny
🇵🇱Warszawa, Dzieciatka Jezus-Centrum Leczenia Obrażeń, Lindleya 4, Poland
Klinika Nefrologii, Transplantologii i Chorob Wewnetrznych - Akademickie Centrum Kliniczne - Szpital AMG
🇵🇱Gdansk, Poland
Oddzial Kiliniczny Nefrologii Hipertensjologii i Transplantologii Nerek SPZOZ, Uniwersytecki Szpital Kliniczny nr 1
🇵🇱Lodz, Poland
Klinika Nefrologii Dializoterapii I Chorob Wewnetrznych - Samodzielny Publiczny Centralny Szpital Kliniczny
🇵🇱Warszawa, Poland
Centro Hospitalar do Porto, EPE - Hospital de Santo Antonio, Departamento de Medicina - Unidade de Imunologia Clinica
🇵🇹Porto, Largo Prof. Abel Salazar, Portugal
Institute of Rheumatology
🇷🇸Belgrade, Serbia
Buddhist Dalin Tzu Chi General Hospital, Vice Superintendent Room
🇨🇳Dalin Town, Chia-Yi county, Taiwan
Chang Gung Memorial Hospital
🇨🇳Taoyuan, Taiwan
Kaohsiung University Medical Hospital
🇨🇳Kaohsiung, Taiwan
Kaohsiung Veterans General Hospital
🇨🇳Kaohsiung, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung City, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Chang-Kung University Hospital
🇨🇳Tainan, Taiwan
Chi Mei Foundation Hospital
🇨🇳Yongkang City, Taiwan
Department of Medicine, King Chulalongkorn Memorial Hospital
🇹🇭Bangkok, Thailand
Ramathibodi Hospital - Division of Allergy, Immunology & Rheumatology, Dept. of Medicine
🇹🇭Bangkok, Thailand
Taipei Veterans General Hospital - Immunology & Rheumatology Office
🇨🇳Taipei, Taiwan
Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine
🇹🇭Bangkok, Thailand
Donetsk Central Municipal Clinical Hospital #1
🇺🇦Donetsk, Ukraine
Kyiv Regional Clinical Hospital
🇺🇦Kyiv, Ukraine
Lviv Municipal Public Clinical Hospital
🇺🇦Lviv, Ukraine
Vinnitsa Regional Clinical Hospital of MoH of Ukraine
🇺🇦Vinnitsa, Ukraine
Kyiv Central Municipal Clinical Hospital
🇺🇦Kyiv, Ukraine
Southeast Regional Research Group
🇺🇸Savannah, Georgia, United States
Feinstein Institute for Medical Research
🇺🇸Manhasset, New York, United States
Wallace Rheumatic Study Center
🇺🇸Los Angeles, California, United States
Private Practice
🇺🇸Camp Hill, Pennsylvania, United States
Intermountain Orthopedics
🇺🇸Boise, Idaho, United States
Nephrology Associates, PC
🇺🇸Flushing, New York, United States
Minsk Regional Clinical Hospital
🇧🇾Minsk, Belarus
Irmandade da Santa Casa de Misericórdia de Sāo Paulo Rua, Dr. Cesário Motta Junior, 112
🇧🇷São Paulo, Brazil
Department of Nephrology, All India Institute of Medical Sciences
🇮🇳New Delhi, Ansari Nagar, India
Sri Ramachandra Medical College & Research Institute (Deemed University)
🇮🇳Porur, Chennai, India
Hospital Santa Izabel, Praca Almeida Couto, 500 - Naxaré
🇧🇷Salvador - BA, Brazil
MHAT "Sveti Georgi", Clinic of Rheumatology
🇧🇬Plovdiv, 15A "Vasil Aprilov" blvd., Bulgaria
Apollo Specialty Hospitals, Lake View Road, K.K., Nagar
🇮🇳Madurai, Tamil Nadu, India
Institute of Kidney Diseases and Research (IKRD) and Institute of Transplantation Sciences (ITS)
🇮🇳Ahmedabad, Asarwa, India
Hospital Aranda de la Parra
🇲🇽Leon, Guanajuato, Mexico
Seth G.S. Medical College & KEM Hospital
🇮🇳Mumbai, India
Dept. of Internal Medicine, Saiful Anwar General Hospital
🇮🇩Malang, Jl. J.A. Suprapto No. 2, Indonesia
Ajou University Medical Center, Ajou University School of Medicine
🇰🇷Suwon, Korea, Republic of
Rayak Hospital
🇱🇧Rayak, Bekaa Valley, Lebanon
Akademii Medycznej w Poznaniu, Zaklad Reumatologii i Immunologii Klinicznej
🇵🇱Poznan, Poland
Institute of Nephrology and Urology Clinical Centre of Serbia
🇷🇸Belgrade, Serbia
RCMI Clinical Research Center, 1st Floor University Hospital Medical Center
🇵🇷San Juan, Puerto Rico
Chang Gung Memorial Hospital - Keelung
🇨🇳Keelung city, Taiwan
M.D. Strazhesko Institute of Cardiology AMS Ukraine
🇺🇦Kyiv, Ukraine
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
San Antonio Kidney Disease Center
🇺🇸San Antonio, Texas, United States
East Bay Rheumatology Medical Group
🇺🇸San Leandro, California, United States
Emory University School of Medicine, Renal Division
🇺🇸Atlanta, Georgia, United States
SOMARC Trials, LLC
🇺🇸Greenbelt, Maryland, United States
North Shore - LIJ Health System
🇺🇸Lake Success, New York, United States
Rheumatology Associates
🇺🇸Chicago, Illinois, United States
AAIR Research Center
🇺🇸Rochester, New York, United States
Seligman Center for Advanced Therapeutics, NYU Hospital for Joint Diseases
🇺🇸New York, New York, United States
Suny Upstate Medical University
🇺🇸Syracuse, New York, United States
Wake Forest University Health Sciences
🇺🇸Winston Salem, North Carolina, United States
Altoona Center for Clinical Research
🇺🇸Duncansville, Pennsylvania, United States
Arthritis Clinic, 371 North Parkway, Suite 400
🇺🇸Jackson, Tennessee, United States
Amarillo Center for Clinical Research
🇺🇸Amarillo, Texas, United States
Healthcare Research Consultants
🇺🇸Tulsa, Oklahoma, United States
Miracle Medical Clinic, 1170 Blalock Road
🇺🇸Houston, Texas, United States
Renal Care Clinic, P.A., 17202 Red Oak Drive
🇺🇸Houston, Texas, United States
Texas Tech University Health Sciences Center
🇺🇸Lubbock, Texas, United States
Clinical Research & Consulting Center
🇺🇸Fairfax, Virginia, United States
Arthritis Northwest PLLC
🇺🇸Spokane, Washington, United States
Centro de Investigaciones Reumatológicas
🇦🇷San Miguel de Tucumán, Provincia de Tucumán, Argentina
Unidad de Alergia, Asma e Inmunología Clínica
🇦🇷Buenos Aires, Argentina
Instituto CAICI
🇦🇷Rosario, Santa Fe, Argentina
Organización Médica de la Investigación
🇦🇷Buenos Aires, Uruguay 725 P.B., Argentina
Centro de Investigaciones en Enfermedades Reumaticas (CIER)
🇦🇷Buenos Aires, Argentina
Gomel Regional Clinical Hospital
🇧🇾Gomel, Belarus
Centro de Investigaciones Reumatologicas y Osteologicas
🇦🇷Buenos Aires, Argentina
Investigación Clínica Polivalente
🇦🇷La Plata, Argentina
Dept Medicine, Level 3 Wallace Freeborn Building, Royal North Shore Hospital, Pacific Highway
🇦🇺St Leonards, Australia
Rheumatology Clinic
🇦🇺Cairns, Australia
Vincents Hospital Daly Building, 41 Victoria Parade Fitzroy
🇦🇺Victoria, Australia
Minsk City Clinical Hospital # 164
🇧🇾Minsk, Belarus
Minsk City Clinical Hospital # 9
🇧🇾Minsk, Belarus
Vitebsk Regional Clinical Hospital
🇧🇾Vitebsk, Belarus
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul-PUCRS
🇧🇷Porto Alegre-RS, Av. Ipiranga, 6690-Conj. 220-Jardim Botanico, Brazil
Hospital e Maternidade Celso Pierro - PUCCampinas, Av. John Boyd Dunlop, s/n
🇧🇷Campinas - Sāo Paulo, Brazil
Hospital Hehopolis
🇧🇷Sao Paulo, Avenida Almirante Delamare, 1534-Sacoman, Brazil
Hospital Geral de Goiania, GO Av Anhanguera 6479 Setor Oeste
🇧🇷Goiania-GO, Goias, Brazil
Hospital de Clinicas - Universidade Estadual de Campinas - UNICAMP, Rua Vital Brasil, 250 - 3º andar - Cidade Universitária Zeferin
🇧🇷Campinas - SP, Brazil
Santa Casa de Misericórdia de BeloHorizonte, Av. Francisco Sales, n. 1111 9 andar Ala D/ CCIH
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Hospital das Clinicas da Faculdade de Medicina da Universidade, Federal de Goiás, Servico de Reumatologia / 2 andar
🇧🇷Goiänia, Goiás, Primeira Avenida s/n Setor Universitário, Brazil
Athritis Clinica de Doenças Reumaticas, Av. Padre Anchieta, 1846 cj 1108
🇧🇷Curitiba - PR, Brazil
Hospital das Clínicas of Medicine School of University of São Paulo (USP) at Ribeirão Preto Rheumatology Department Avenida dos
🇧🇷Ribeirão Preto, Brazil
Hospital de Clinicas de Porto Alegre - HCPA
🇧🇷Porto Alegre-RS, Brazil
MHAT "Sveti Ivan Rilski", Clinic of Rheumatology
🇧🇬Sofia, 13 "Urvich" Street, Bulgaria
Fakultni nemocnice Plzen, Oddeleni klinické farmakologie
🇨🇿Plzen, Edvarda Benese, Czech Republic
VFN Prahal Lékarská fakulta, Klinika detského a dorostového lékarstvi,
🇨🇿Praha 2, Ke Karlovu, 09 Praha 2,, Czech Republic
Revmatologický ústav
🇨🇿Praha 2, Czech Republic
Medizinische Klinik und Poliklinik IV des Universitätsklinikum Lepizig, Rheumatologie
🇩🇪Leipzig, Liebigstrasse 22, Germany
Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej
🇵🇱Lublin, Poland
Herz and Rheumazentrum Kerckhoff-klinik GmbH
🇩🇪Bad Nauheim, Benekestrasse 2-8, Germany
Charité-Unversitätmedizin Berlin, CharitéCentrum Inn ere Medizin und Dermatologie
🇩🇪Berlin, Chariteplatz 1, Germany
Inha University Hospital
🇰🇷In Cheon, Korea, Republic of
Hospital Star Medica
🇲🇽Morelia, Michoacan, Mexico
Klinika Chorob Wewnetrznych i Reumatologii - Gornoslaskie Centrum Medyczne, SPSK Nr 7 SL A M
🇵🇱Katowice, Poland
Klinika Chorób Tkanki Łącznej
🇵🇱Warszawa, Poland
Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Egas Moniz, Unidade de Reumatologia
🇵🇹Lisboa, Rua da Junqueira, 126, Portugal
Hospital de Sāo Jeāo, Servico de Nefrologia
🇵🇹Porto, Portugal
Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria - Reumatologia
🇵🇹Lisboa, Av. Prof. Egas Moniz, Portugal
"Sf. Maria" Clinical Hospital
🇷🇴Bucharest, Romania
Centro Hospitalar de Vila Nova de Gaia
🇵🇹Vila Nova de Gaia, Rua Conceicao Fernandes, Portugal
Rehabilitation Clinical Hospital
🇷🇴Iasi, Romania
"Ion Stoia" Center of Rheumatic Diseases
🇷🇴Bucharest, Romania
Emergency Clinical County Hospital Cluj
🇷🇴Cluj Napoca, Romania
University Medical Centre "Zvezdara", Clinical Department for Renal Diseases, Dimitrija Tucovica 161
🇷🇸Belgrade, Serbia
Institute of Prevention, Treatment and Rehabilitation of Rheumatoid and Cardiovascular Patients "Niska Banja"
🇷🇸Niska Banja, Serbia
Reumatologicka ambulancia Fakultna nemocnica F D Roosevelta
🇸🇰Banska, Bystrica, Slovakia
Reumatologicka ambulancia Fakultna nemocnica s poliklinikou Milosrdni bratia spol s r o
🇸🇰Bratislava, Slovakia
Hospital Clinic i Provincial de Barcelona, Centre Ciutat, Facultat de Medicina, Servicio de Enfermedades Autoinmunes
🇪🇸Barcelona, Calle Villarroel, 170, Spain
Hospital Universitari Vall d'Hebron, Servicia Medicina Interna, Edificio General, 3a Planta
🇪🇸Barcelona, Paseo Valle de Hebron 119-129, Spain
Hospital Universitario La Paz, Servico de Medicine Interne Planta 10
🇪🇸Madrid, Paseo de la Castellana 261, Spain
University Lupus Clinic of the Department of Clinical Medicine, Faculty of Medicine, University of Colombo, P.O. Box 271, No 25,
🇱🇰Colombo, Kynsey Road, Sri Lanka
Chang Gung Memorial Hospital - Taipei
🇨🇳Taipei, Taiwan
Hong Kong University, Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong