Effect of Cefazolin and Normal Saline Irrigation on Surgical Site Infections (SSIs)

Not Applicable

Completed

• Conditions: Surgical Site Infections
• Interventions: Other: Cefazolin irrigation; Other: Normal Saline Irrigation

• Registration Number: NCT01566734
• Lead Sponsor: Hormozgan University of Medical Sciences

Brief Summary

This study conducted to assess the effects of normal saline or cefazolin irrigation on the incidence of SSIs.

Hypothesis:

Normal saline or cefazolin irrigation decreases the incidence of SSIs.

Detailed Description

All pregnant women who underwent cesarean after 6 hours passed their rupture of membrane and attended to Shariati Hospital of Bandarabbass were eligible for our study.

Study Timeline

• Study Start: 2010-12
• Primary Completion: 2011-12
• Study Completion: 2012-02
• Study First Submitted: 2012-03-26
• Study First Submitted QC: 2012-03-28
• Study First Posted: 2012-03-29
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-12
• Last Update Posted: 2012-10-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

• pregnant women
• 6 hours passed their rupture of membrane
• needed to undergo cesarean

Exclusion Criteria

• allergy to penicillin
• allergy to cefazolin
• history of immunosuppressive drug use
• gestational diabetes mellitus
• preeclampsia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cefazolin	Cefazolin irrigation	after the surgery and before closing up the patients, 2 grams of cefazolin in 5 cc of distilled water was used to irrigate the patients
Normal Saline	Normal Saline Irrigation	after the surgery and before closing up the patients, 150 cc of normal saline was used to irrigate the patients

Primary Outcome Measures

Name	Time	Method
SSI	one week after discharge

Trial Locations

Locations (1)

Shariati Hospital; 🇮🇷 Bandar 'Abbas, Hormozgan, Iran, Islamic Republic of