Comparison of blood parameters (CRP and Albumin) which serve as a marker for stress and nutritional status, and their role in assessing complications after surgery including duration of hospital stay, reintervention and readmissions after a major abdominal surgery

Completed

Conditions: Malignant neoplasms of digestive organs, (2) ICD-10 Condition: K00-K95||Diseases of the digestive system,

Brief Summary: To identify patients at risk and to optimizeperioperative care, a basic and reliable parameter representing surgical stressis crucial. In clinical settings, postoperative blood C-reactiveprotein (CRP) levels have been used to assess postoperative inflammatorystatus. However, the slow kinetics of CRP as a predictor of stress is amajor drawback. Peak values are noted only on days 2 or 3 following surgery,which may be too late for early preventive measures. Additionally, albumin is a common nutritional markerand outcome predictor exhibits a rapid response to surgical stress, making itan ideal tool for gauging and predicting a difficult postoperative course. Therefore, the CRP to albumin ratio will accuratelyreflect the nutritional and inflammatory condition and may act as a marker forthe stress response post-surgery and a possible indicator of unfavorableoutcomes.

Recruitment & Eligibility

Inclusion Criteria

1.Patient undergoing Major elective gastrointestinal surgery in General Surgery Department, GIS Department and Onco-surgery Department at KH, Manipal 2.Patient consenting to be a part of the study.
3.Patient >18 years of age.
4.Patient undergoing neoadjuvant chemotherapy with no evidence of malnutrition preoperatively.

Exclusion Criteria

1.Patient not willing to participate in the surgery.
2.Patient undergoing emergency GI surgery.
3.Patients undergoing surgeries which are not defined under â€œmajorâ€ criteria ( eg.
lap chole ) according to WRHA criteria 4.Patient failing to follow up.
5.Patient <18 years of age.
6.Patient with existing chronic inflammatory conditions.
7.Patientâ€™s with comorbidities causing organ dysfunction (eg-COPD,CKD) ( ASA grade 3 and above ) 8.Patient undergoing albumin infusion pre operatively 9.Patient discharging <48 hours of surgery 10.Patient with operative mortality.

Primary Outcome Measures

Name	Time	Method
To assess the role of CRP/Albumin ratio in predicting post-operative morbidity.	30 days of postoperative period

Secondary Outcome Measures

Name	Time	Method
Relationship between CRP/Albumin ratio and	30 days morbidity.

Locations (1): Kasturba Hospital
🇮🇳
Udupi, KARNATAKA, India
Kasturba Hospital
🇮🇳Udupi, KARNATAKA, India
Dr Srinidhi S
Principal investigator
8197914790
srinidhi1.kmcmpl2022@learner.manipal.edu