NL-OMON44283已完成不适用
An open label positron emission tomography (PET) imaging study using 89Zirconium to investigate the biodistribution of anti-HER3 monoclonal antibody (mAb) GSK2849330 and characterize its dose receptor occupancy relationship in subjects with advanced HER3-positive solid tumors - study 200980
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Males and females, 18 years and above.
- •Tumors with HER3 expression.
- •No standard therapeutic alternatives.
- •ECOG Performance Status 0-1.
- •Measurable disease suitable for PET imaging.
- •Females of childbearing potential: adequate method of contraception during study.
- •Men must use adequate contraception during study.
排除标准
- •Active central nervous system metastases.
- •Prior HER3- directed treatment.
- •Recent anti-cancer therapy or major surgery.
- •Allergic reaction to previous biological therapy.
- •Prohibited medications during study including immunesuppressants.
- •Significant CV risk, see protocol page 42 for details.
- •Pregnancy or breastfeeding
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