EAMA Sarcopenia in Acute Care Patients in 9+European Countries

Terminated

• Conditions: Malnutrition; Sarcopenia

• Registration Number: NCT04039620
• Lead Sponsor: Parc de Salut Mar

Brief Summary

This collaborative study in 9 geriatrics units across Europe aims to apply emerging research to clinical practice, following the "Action-Research Philosophy" (11). The overall goal is to improve care in patients with - and help prevent - sarcopenia. Understanding the frequency of and risk factors for developing sarcopenia in an acute hospital setting, may help shed light on potential interventions and thus inform the development of future therapeutic strategies. It involves crucial implications for research, clinical practice, and policy towards optimal aging.

Detailed Description

Background: Sarcopenia is a nutrition-related disease leading to physical impairment and adverse clinical outcomes. Data regarding its characteristics in hospitalized patients are limited.

Aim: This study will assess in older patients admitted to acute medical wards, the prevalence, incidence, and risk factors for development of sarcopenia, or alteration in its severity, and evaluate associated clinical adverse outcomes.

Methods: This collaboratively-designed, longitudinal prospective observational study will be carried out in patients aged \>70 admitted to acute geriatric units in 9 European centers. The new sarcopenia diagnostic criteria of the European Working Group on Sarcopenia 2 (EWGSOP2) will be tested at admission and discharge, using isometric handgrip dynamometry, gait speed, and, pragmatically, calf circumference. There will be 3- and 12-month telephone follow-up (including the SARC-F questionnaire).

Discussion: Our study will be the first collaboration to assess the prevalence and incidence of sarcopenia (EWGSOP2) and its risk factors in hospitalized patients across Europe.

Study Timeline

• Study Start: 2019-03-06
• Study First Submitted: 2019-03-06
• Study First Submitted QC: 2019-07-29
• Study First Posted: 2019-07-31
• Primary Completion: 2021-04-02
• Status Verified: 2023-04
• Study Completion: 2023-04-02
• Last Update Submitted: 2023-04-02
• Last Update Posted: 2023-04-05

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 366

Inclusion Criteria

• Patients aged >70 admitted to acute hospital medical units

Exclusion Criteria

• Length of hospital stay anticipated to be <24 hours
• Hip/lower limb fractures
• Major amputations of the lower leg
• Terminally ill patients admitted for palliative care

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of sarcopenia as defined by the European consensus on definition and diagnosis (EWGSOP2)	One year (March 2019-March 2020)	Incidence of sarcopenia in acute hospitalized older patients.
Prevalence of sarcopenia as defined by the European consensus on definition and diagnosis (EWGSOP2)	One year (March 2019-March 2020)	Prevalence sarcopenia in acute hospitalized older patients.

Trial Locations

Locations (1)

Sanchez Rodríguez; 🇪🇸 Barcelona, Spain