EUCTR2009-016785-88-BE进行中（未招募）不适用
Dexmedetomidine pharmacokinetics-pharmacodynamicsin mechanically ventilated children with single-organ respiratory failure
niversity Hospital Ghent0 个研究点开始时间: 2009年11月12日最近更新:
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •- patients admitted to the paediatric intensive care unit
- •- expected to require at least 24h of mechanical ventilation
- •- patient age : 1 month-15 years
- •- patients with single-organ respiratory failure
- •Are the trial subjects under 18? yes
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) no
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •- patients with neurologic conditions that prohibit an evaluation of adequate analgosedation
- •- no arterial catheter in place at inclusion
- •- patients who have received another investigational drug within 30 days
- •- patients on continuous infusion with neuromuscular blockers
- •- patients with a life expectancy <72h
- •- patients with a known allergy to lorazepam, midazolam and/or morphine
- •- heart block
- •- pre-existing bradycardia
- •- hemodynamically unstable patients (Wernovsky index > 16 points) after full fluid replacement with cristalloid
- •- paients with significant renal insufficiency (creatinine plasma level 1 month-5 year : > 1 mg/dl ; 5-10 years : >1.2 mg/dl; > 10 years : > 1.5 mg/dl)
- •- patients with significant hepatic insufficiency (aspartate aminase >950 UI/L and prothrombin time < 60 or INR >1.4)
- •- previous treatment with a2-adrenoreceptor agonist clonidine within 14 days
研究者
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