Pregnancy outcome in infertile women following intrauterine administration of peripheral blood mononuclear cells: a prospective study

Not Applicable

Completed

• Conditions: Infertility; Pregnancy and Childbirth

• Registration Number: ISRCTN12384569
• Lead Sponsor: Institute of Reproductive Medicine

Brief Summary

2020 Results article in https://www.researchgate.net/publication/344249261_Intrauterine_Infusion_of_Human_Autologous_Peripheral_Blood_Mononuclear_Cells_Improves_In_Vitro_Fertilization_Success_in_Infertile_Women (added 06/12/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-08-09
• Study Completion: 2020-04-30
• Last Update Posted: 21 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 95

Inclusion Criteria

1. Female
2. Aged 21-45 years
3. Primary and secondary infertility
4. At least 3 failed IVF-FET

Exclusion Criteria

1. Adenomyosis
2. Congential uterine anomalies
3. Baseline FSH> 12 IU
4. Donor oocyte recipients
5. Gestational surrogates

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Pregnancy rate at 12-weeks<br> 2. Miscarriage rate at 12-weeks<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Endometrial thickness measured using ultrasound examination at baseline and 12-weeks<br> 2. Endometrial vascularity measured by transvaginal sonography (TVS) and Applabaum scoring was done evaluate the vascularity at baseline and 12-weeks<br>