Auditory-motor Coupling in Multiple Sclerosis with Cerebellar Lesions

Not Applicable

Completed

• Conditions: Multiple Sclerosis; Cerebral Lesion
• Interventions: Other: motor entrainment to auditory cues and music during walking on quality of movement

• Registration Number: NCT04639401
• Lead Sponsor: Hasselt University

Brief Summary

This study is a case-control observational study, involving persons with multiple sclerosis and healthy controls. The study contains 1 descriptive and 4 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, at different tempi and alignment strategies. In the latter three sessions, apart from outcome measures of synchronization the following will be collected as well: spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-09
• Study First Submitted: 2020-11-09
• Study First Submitted QC: 2020-11-17
• Study First Posted: 2020-11-20
• Status Verified: 2024-04
• Primary Completion: 2025-01-01
• Study Completion: 2025-02-21
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• diagnosis of Multiple sclerosis >1 year,
• type of lesions: cerebellar lesions,
• walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted).

Exclusion Criteria

• relapse 3 months prior to enrollment,
• cognitive impairment impeding understanding of instructions,
• beat amusia,
• deafness,
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
persons with Multiple Sclerosis	motor entrainment to auditory cues and music during walking on quality of movement	-
Healthy controls	motor entrainment to auditory cues and music during walking on quality of movement	-

Primary Outcome Measures

Name	Time	Method
EEG	week 2	64 channel EEG measurement (only conducted in 4 PwMS and HC) -\> neural correlates of entrainment
Muscle weakness	week 1	Motricity Index of dorsi flexors, knee extensors and hip flexors -
Perceptual tempo and rhythm judgements	week 2	subjective indications in regards to what the participants hear in terms
6 minute walking test	week 1	gait pattern and endurance
Brief repeatable battery of Rao	week 1	cognitive test
MS walking scale -12	week 1	impact of MS on walking ability
Spasticity	week 1	Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts
Ataxia	week 1	Scale for the assessment and rating of ataxia
Time up and Go test	week 1	balance
Symbol digit mobility test	week 1	cognitive test
Modified fatigue impact scale	week 1	effect of fatigue
Dual task questionnaire	week 1	troubles a person have when performing a dual task during daily activity
Relative phase angle	week 5	asynchrony in time to quantify synchronization accuracy (in degrees and in milliseconds respectively)
Asynchrony	week2	timing difference between the tap and the beat
Dynamic gait index	week 1	dynamic balance
Resultant Vector Length	week 5	synchronisation consistency
Activities-specific balance confidence scale	week 1	rating of balance confidence in performing activities of daily life
Hospital Anxiety and Depression Scale	week 1	determine the levels of anxiety and depression
Stroop test 0	week 1	cognitive test

Secondary Outcome Measures

Name	Time	Method
Stride length	week 5	distance between consecutive steps (cm)
Perceived cognitive and physical fatigue	week 5	A visual analogue scale will be used, and participants will be asked to rate their perceived cognitive and physical fatigue levels before and after each experimental walking conditions
Perceived walking speed	week 5	A Likert scale will be used, and participants will be asked to rate their perceived walking speed relative to their usual walking after each experimental walking conditions
Cadence	week 5	number of steps per minute
speed	week 5	gait velocity (m/s)
Double Support	week 5	time that both legs are in contact with the floor (mseconds)
Perceived motivation	week 5	A Likert scale will be used, and participants will be asked to rate their perceived motivation of walking after each experimental walking conditions

Trial Locations

Locations (2)

National MS Center Melsbroek; 🇧🇪 Melsbroek, Belgium

Noorderhart Revalidatie & MS centrum; 🇧🇪 Overpelt, Belgium