Calculation of Platelet-rich Plasma Preparation Yield From Baseline CBC Platelet Count
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Platelet yield
Study Overview
Brief Summary
This is a study to determine 1) the consistency of platelet-rich plasma produced by several methods, and 2) whether the platelet content of platelet-rich plasma can be accurately estimated from a baseline CBC platelet count.
Detailed Description
In the first phase of this study a baseline CBC platelet count will be performed on each subject and then platelet-rich plasma (PRP) prepared from the same blood sample by six different methods. The platelet count will be measured in each PRP preparation and compared to the CBC platelet count to determine the platelet yield for each method.
In the second phase of the study a baseline CBC platelet count will be performed on each subject and then platelet-rich plasma (PRP) prepared from the same blood sample by six different methods. The CBC platelet count will be used to calculate the estimated platelet content of each sample/method based on the platelet yields determined in the first phase. The platelet count will be measured in each PRP preparation and compared to the estimated platelet content to determine the predictive accuracy for each method.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 21 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •English speaking
Exclusion Criteria
- •platelet count < 150,000
- •platelet count > 350,000
- •History of blood disorder
- •History of altered platelet function
- •History of chemotherapy or radiation therapy
Outcomes
Primary Outcomes
Platelet yield
Time Frame: within 8 hours of blood draw
the number of platelets in a PRP sample as a percentage of the number of platelets in the blood from which the PRP was prepared.
Platelet yield estimate accuracy
Time Frame: within one month of final data collection
standard deviation of the difference between the estimated platelet yield and the actual platelet yield.
Secondary Outcomes
No secondary outcomes reported
Investigators
Theodore Harrison, MD
Principal Investigator
Harrison, Theodore, M.D.