CHOICE study: time-dependent modulation of stress-induced effects on social decision making

Completed

Conditions: Effecten van stress in gezonde vrijwilligers
Sociale decision making under stress

Registration Number: NL-OMON38225

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

Volunteers are eligible if they are 18 years or older and healthy

Exclusion Criteria

* smoking (positive urine screen)
* any psychiatric disorder
* current or past drug use (positive urine screen on the presence of amphetamines (including MDMA), barbiturates, cannibinoids, benzodiazepines, cocaine and opiates), and alcohol use 24 hours prior to testing
* present use of any medication which might influence the stress response, including benzodiazepines, psychotropics, beta blockers, ACE inhibitors and any hormonal treatment excluding any hormonal anticonceptives
* lack of fluency in the Dutch language
* speech impairments;Acute exclusion criteria are:
- any acute illness
- fever
- having a severe cold
- physical exertion within the last 2 hours
- drink other than water or any food within the last 2 hours
- ingestion of coffee or any caffeine-containing drink within the last 4 hours
- alcohol use on the testing day (breath alcohol level above 0%)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• performance on various social decision making tasks</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• saliva cortisol and alpha amylase response<br /><br>• autonomic heart rate, blood pressure and skin temperature response<br /><br>• saliva immune response<br /><br>• subjective stress response using questionnaires.<br /><br>• Genotype<br /><br>• Epigenetic DNA methylation</p><br>