An intervention study of optimizing algorism-based pharmacological treatment for schizophrenia

Not Applicable

• Conditions: Schizophrenia

• Registration Number: JPRN-UMIN000004931
• Lead Sponsor: Department of Neuropsychiatry Keio University School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-22
• Study Completion: 2011-06-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

1.We exclude patients are in remission status, and showing mild or milder symptoms in all 8 subscales on PANSS. Treatment-resistant cases: We exclude patients receive several antipsychotics (more than chlorpromazine-conversion dosage of 2000mg/ day during at least last 6 months, or taken more than 7 types of antipsychotics), but show a score less than 30 on FACT-SZ (definitely requiring hospitalization level). 2.Patients did not show any sufficient response to more than two kinds of atypical antipsychotics, or patients have intolerability to atypical antipsychotics so far. 3.Patients have severe underlying diseases, such as diabetes, substance dependence at present, serious physical disease, possibility of pregnancy, severe intellectual disorder, and organic brain disorder. 4.Patients show comorbid personality disorders diagnosed by DSM-IV. 5.Patients have high probability of attempting suicide. 6.Patients show an allergic reaction to a medication or have a history of the allergy. 7.Patients do not agree to participate in the study on a written informed consent form. 8.Patients are not able to receive examination and assessments for pharmaceutical therapy on designated date.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Positive and Negative Syndrome Scale

Secondary Outcome Measures

Name	Time	Method
Clinical Global Impression Scale-Schizophrenia Version (CGI-SCH) Global Assessment of Functioning (GAF) Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS) Targeted Inventory on Problem in Schizophrenia (TIP-Sz) and Assessment for Comprehensive Treatment of Schizophrenia (FACT-Sz) Short-form 36 v2 Health Survey (SF-36v2) Subjective Wellbeing under Neuroleptic Treatment Scale (SWN-J)