Recoil Feasibility Study for the Treatment of Atherosclerotic Lesions in the Infrapopliteal Arteries Comparing Serration Angioplasty (Serranator® Device) vs. Plain Balloon Angioplasty (POBA)
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 3
- 主要终点
- Presence of post treatment recoil
研究概览
简要总结
The study objective is to assess the ability to define and measure post treatment recoil in infrapopliteal arteries. Preliminary evidence as to the differences between serration angioplasty and standard balloon angioplasty as defined by post treatment recoil, lumen gain, and dissection will be collected.
详细描述
Multi-center, feasibility study treating up to 20 atherosclerotic lesions in the infrapopliteal arteries. The study will capture angiographic imaging (pre, during, post, and post 15 mins) for all lesions, and a subset (up to 10) of IVUS imaging data (pre, post, and post 15 mins), to compare serration angioplasty vs standard angioplasty and its effects on vessel recoil and final diameter stenosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female of >18 years old.
- •Women of childbearing potential must have a negative urine pregnancy test within 7 days of index procedure.
- •Subject or subject's legal representative has been informed of the nature of the study, agrees to participate, and comply, and has signed the consent form.
- •Subject has Rutherford Clinical Category 3, 4, 5, or
- •Angiographic Inclusion Criteria:
- •Target lesion(s) has stenosis >70% by visual assessment;
- •De-novo, or non-stented re-stenotic lesions;
- •Reference vessel diameter is between 2.5 mm and 3.5 mm, inclusive;
- •Target lesions involve infrapopliteal tibial arteries including pedal;
- •A target lesion may consist of one long or multiple serial lesions that are up to and including 12 cm in length;
- •If a second lesion is identified in another vessel, the second lesion can also be treated and if treated will be treated with the alternate treatment.
排除标准
- •Evidence of aneurysm or acute thrombus in the target vessel.
- •Subject has an allergy to contrast medium that cannot be pretreated.
- •Subject is pregnant or breastfeeding.
- •Angiographic Exclusion Criteria:
- •Acute Total Occlusions; evidence of acute thrombus formation by angiography.
- •In-stent restenotic lesions.
- •Inability to cross the lesion with the assigned study device.
- •Treatment of target lesion with atherectomy.
结局指标
主要结局
Presence of post treatment recoil
时间窗: 15 minutes post procedure
Obtain preliminary data on post treatment recoil in infrapopliteal arteries utilizing angiographic and IVUS data following serration angioplasty and standard angioplasty.
次要结局
未报告次要终点