Verticality Perception - Modulatory Effect of a Rotating Optokinetic Stimulus on the Haptic Vertical in Healthy Human Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Trial-to-trial variability of aligning a rod along perceived direction of gravity while an optokinetic stimulus is presented.
研究概览
简要总结
The investigators previously shown that a rotating optokinetic stimulus results in shifts of the subjective visual vertical in healthy human subjects. However, the origin of these shifts is still poorly understood. Both torsional displacement of the eyes and a shift in the internal estimate of direction of gravity have been proposed as potential explanations. Here the investigators use a vision-independent setup to differentiate between these two hypotheses, predicting no impact of a rotating stimulus on the subjective haptic vertical if torsion triggers the shift.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ages 18-65 years
- •informed consent
- •absence of exclusion criteria
排除标准
- •peripheral-vestibular deficit
- •disturbed consciousness
- •history of sensory deficits
- •visual field deficits
- •other neurological or systemic disorder which can cause dementia or cognitive dysfunction
- •intake of antidepressants, sedatives, or neuroleptics
- •pregnancy, unless excluded by a negative pregnancy test
- •known neck pain or status post neck trauma
研究组 & 干预措施
intervention arm
all participants will be assigned to the same arm. Interventions applied include presenting a visual line or a rod with or without a moving (rotating) background while being in different whole-body roll positions. Participants will be asked to adjust the line or the rod along perceived direction of gravity.
干预措施: changes in whole-body roll position and visual/haptic stimuli presented (Other)
结局指标
主要结局
Trial-to-trial variability of aligning a rod along perceived direction of gravity while an optokinetic stimulus is presented.
时间窗: 60 minutes
This outcome parameter focuses on the trial-to-trial variability of rod alignments along perceived direction of gravity when presenting a visual bias cue (i.e. an optokinetic rotatory stimulus).
Adjustment errors of aligning a rod along perceived direction of gravity while an optokinetic stimulus is presented.
时间窗: 60 minutes
This outcome parameter focuses on the adjustment errors of the subjective haptic vertical while presenting a visual bias (i.e. an optokinetic rotatory stimulus).
次要结局
- Comparison of adjustment errors between the subjective haptic vertical and the subjective visual vertical(60 minutes)
- Comparison of adjustment errors of perceived vertical using the subjective haptic vertical with and without presenting an optokinetic stimulus(60 minutes)