The Effect of Coenzyme Q10 Pretreatment on Ovarian Reserve in Women Undergoing Hysterectomy with Bilateral Salpingectomy: A Randomized, Double-Blind, Placebo-Controlled Trial
Phase 1
Completed
- Conditions
- the ovarian reserve change using anti-mullerian hormone levels before and 6 weeks after undergoing hysterectomy with bilateral salpingectomyovarian reserveanti-mullerian hormonehysterectomyCoenzyme Q10
- Registration Number
- TCTR20230926003
- Lead Sponsor
- Ramatibodi hospital, Mahidol university
- Brief Summary
women undergoing hysterectomy with bilateral salpingectomy had a significant decline in ovarian reserve when determined by serum AMH level at 6 weeks postoperation. However, the ovarian reserve changes are not significantly different in women with CoQ10 pretreatment for 2 weeks when compared to placebo.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 43
Inclusion Criteria
1. The women age between 25 to 45 years old
2. Diagnosed with leiomyoma or adenomyosis scheduled for hysterectomy with bilateral salpingectomy
3. Provided signed informed consent
Exclusion Criteria
1. History of ovarian surgery
2. Anticipated ovarian cystectomy
3. Hormonal use within 3 months before surgery
4. Known allergies to CoQ10 or starch
5. Suspected malignancy
6. Drug use that interacts with CoQ10 , for example; warfarin or statin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method percentage AMH change 2 weeks before surgery and 6 weeks after surgery percentage AMH change between pre- and post-operative level
- Secondary Outcome Measures
Name Time Method safety profile after two weeks course of intervention or placebo side effects report by participants,Liver and renal function 6 weeks after complete course of intervention or placebo SGOT, SGPT, BUN, creatinine levels