Characterising Left Atrial Function and Compliance in Atrial Fibrillatio
Not Applicable
Recruiting
- Conditions
- Atrial FibrillationCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12620000639921
- Lead Sponsor
- niversity of Adelaide
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 170
Inclusion Criteria
Symptomatic AF with scheduled AF ablation procedure and failed >1 antiarrhythmic drug therapy
Capable of providing written consent
Ability to perform an exercise stress test on a cycle ergometer
Exclusion Criteria
Ejection fraction <50% by transthoracic echocardiography (TTE) determined by Simpsons biplane method at the time of enrolment
Previous diagnosis of a cardiopmyopathy
Moderate to severe valvulopathy
Prior diagnosis of pulmonary hypertension
Active malignancy
Musculoskeletal diseases or injuries limiting exercise capacity
Severe chronic obstructive pulmonary disease
Moderate to severe valvulopathy
Unable to provide written consent
Unable to exercise
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eft atrial stiffness assessed by measuring left atrial pressure changes with direct infusion of isotonic saline into the left atrium. Left atrial pressure will be assessed by using the standard pressure transducer used for transeptal puncture during the AF ablation procedure. [At the time of catheter ablation]
- Secondary Outcome Measures
Name Time Method