Evaluation of left atrial(LA) function using left atrial fractional area change (LAFAC) as a diagnostic tool for cardiac amyloidosis

Not Applicable

Recruiting

• Conditions: Heart failure preserved LVEFcardiac amyloidosisHypertensive heart disease (HT heart disease)Hypertrophic cardiomyopathy (HCM)Constrictive pericarditisLeft atrial fractional area change (LAFA

• Registration Number: TCTR20190822001
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-22
• Study Completion: 2020-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Patients diagnosed cardiac amyloidosis confirmed diagnostic criteria and tissue or bone marrow biopsy showing amyloid deposit.
2. Echocardiography findings concomitant with cardiac amyloidosis and diagnosed by at least two experienced cardiologists.
3. Hypertensive heart disease patients with LVH(LVMI>115g/m2in male or > 95 g/m2 in female with RWT > 0.42) and age matched to patients in cardiac amyloidosis group.
4. HCM patients with LVH(LVMI>115g/m2 in male or>95g/m2in female with RWT > 0.42)
5. Constrictive pericarditis patients with echocardiographic finding concomitant with Mayo Clinic echocardiographic criteria and diagnosed by at least two experienced cardiologists.
6. Healthy subjects without heart disease with age matched with patients in cardiac amyloidosis group

Exclusion Criteria

1. Inadequate quality or unavailable echocardiographic study
2 . Patients with atrial fibrillation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
cut-off value of LAFAC for diagnosing cardiac amyloidosis 12 months Echocardiographic measurement of left atrial area and calculate in formula : (ESA †EDA)/ESA x 100

Secondary Outcome Measures

Name	Time	Method
Value of LAFAC between cardiac amyloidosis and HT heart disease 12 months Echocardiographic measurement of left atrial area and calculate in formula : (ESA †EDA)/ESA x 100,Value of LAFAC between cardiac amyloidosis and HCM 12 months Echocardiographic measurement of left atrial area and calculate in formula : (ESA †EDA)/ESA x 100,Value of LAFAC between cardiac amyloidosis and constrictive pericarditis 12 months Echocardiographic measurement of left atrial area and calculate in formula : (ESA †EDA)/ESA x 100,Value of LAFAC between cardiac amyloidosis and non cardiac disease patient 12 months Echocardiographic measurement of left atrial area and calculate in formula : (ESA †EDA)/ESA x 100