ortriptyline in knee arthritis

Phase 2

Completed

• Conditions: Osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12614000683639
• Lead Sponsor: Dr Ben Hudson

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-06-27
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Primary knee OA defined according to American College of Rheumatology (ACR) classification criteria (knee pain plus 3 of: age >50 years, stiffness <30 mins, crepitus, bony tenderness, bony enlargement, no palpable warmth).
2. Pain severity of >=20 points on the Western Ontario and McMaster Universities (WOMAC) numerical rating scale (range 0 to 50 points) at the study knee.

Exclusion Criteria

01. Prior joint replacement surgery on the study knee
02. Intra-articular steroid injection within the previous 3 months
03. Secondary OA (OA due to inflammatory arthritis [eg gout, rheumatoid arthritis, juvenile arthritis], septic arthritis or trauma)
04. Known hypersensitivity to nortriptyline or history of adverse reaction to any tricyclic antidepressant
05. Current use of nortriptyline or other antidepressants, or amiodarone
06. Within 6 months of myocardial infarction
07. Heart block
08. Postural hypotension
09. Pregnancy
10. Hyperthyroidism or phaeochromocytoma under current investigation or treatment
11. History of epilepsy or other seizure
12. History of bipolar disorder or manic episode
13. History of increased intra-ocular pressure or history of angle-closure glaucoma
14. Chronic constipation
15. Urinary retention

Study & Design

• Study Type: Interventional
• Study Design: Not specified