Buffered bicarbonate solutions for liver transplantatio

Phase 2

Completed

• Conditions: Liver transplantation; iver transplantation; Surgery - Other surgery; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12619001227189
• Lead Sponsor: Professor Rinaldo Bellomo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-05
• Study Completion: 2022-07-31
• Last Update Posted: 22 August 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

Adult liver donor recipients aged 18 years or older
Primary deceased donor liver transplantation including donation after brain death and donation after cardiac death
Redo deceased donor liver transplantation

Exclusion Criteria

Paediatric recipients aged 17 years of less
Combined liver-kidney transplant
Combined liver-small bowel transplant
Fulminant hepatic failure
End stage renal disease defined as a serum creatinine greater than 300 micromol per litre
Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum measurement of metabolic acidosis, reflected by standard base excess[5-minutes post reperfusion of the donor liver]

Secondary Outcome Measures

Name	Time	Method
Serum bicarbonate level[5-minutes post liver donor perfusion];Serum measurement of arterial pH[At the commencement of the operation, approximately 45-minutely during and at the end of the operation where an arterial blood gas is measured as part of routine intraoperative care.];Serum assessment of arterial blood electrolytes (sodium, potassium, calcium and chloride) as recorded in the patient's medical record.[At the commencement of the operation, approximately 45-minutely during and at the end of the operation where an arterial blood gas is measured as part of routine intraoperative care.];intensive care unit admission as recorded in the patient's medical record[duration of intensive care unit admission following liver transplantation as recorded in the patient's medical record]