A study to examine whether giving steroids in low dose daily is more effective than if given on alternate days, in controlling disease activity in patients with frequently relapsing nephrotic syndrome
- Conditions
- Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
- Registration Number
- CTRI/2019/01/017091
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Children aged 2-18 yr with frequently relapsing or steroid dependent nephrotic syndrome
Written informed consent from parents
Steroid resistant nephrotic syndrome
Congenital nephrotic syndrome
Nephrotic syndrome secondary to systemic disease (systemic lupus erythematosus, IgA nephropathy, infection with HIV or hepatitis B or C)
Estimated glomerular filtration rate below 60 ml/min/1.73 sq. m
Recent (during the last 6-months) therapy with long term alternate day prednisolone for >3-months, levamisole, cyclophosphamide or mycophenolate mofetil
History of therapy with cyclosporine, tacrolimus or rituximab
Significant steroid toxicity, as defined by BMI >2 SDS; stage 2 hypertension; cataract, glaucoma; fasting glucose levels >100 mg/dl; history of steroid psychosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method