Predictors of Early Chest Infection in Acute Ischemic Stroke
- Conditions
- Acute Ischemic StrokePneumonia
- Registration Number
- NCT00906542
- Lead Sponsor
- University of Rostock
- Brief Summary
Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects. In previous studies, a number of clinical (e.g., dysphagia, severe neurological impairment, mechanical ventilation), radiological (e.g., large infarctions in the territory of middle cerebral artery, insular infarction) and biochemical (e.g., increased serum levels of C-reactive protein, decreased levels of CD4+ T-lymphocytes) findings have been reported as risk factors of stroke-related chest infection. The present study (PRECAST) aims to identify a small set out of these previously described risk factors that can predict stroke-related pneumonia with high sensitivity and specificity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 530
- acute ischemic stroke
- admission to the neurological intensive care unit or stroke unit within 24 hours after stroke onset
- clearly assessed brain lesion location
- previous large (non-lacunar) stroke
- chest infection present already on hospital admission
- mechanical ventilation already on day 1 or 2 after hospital admission
- treatment with immunosuppressive drugs
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method diagnosis of chest infection within 7 days after stroke days 1-7 after stroke
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Rostock, Department of Neurology
🇩🇪Rostock, Germany