Graded Exercise Hypoxia Testing
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- Mayo Clinic
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- PaO₂/FiO₂ Ratio
研究概览
简要总结
The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Physically active (≥150 minutes of moderate physical activity per week)
排除标准
- •Contraindications to exercise testing
- •Currently pregnant
- •Musculoskeletal or metabolic disease
- •Allergies to lidocaine
- •Body-mass index ≤18 or ≥35 kg·m-2
- •Pacemaker
- •No confounding cardiorespiratory disease
- •Persistent tobacco use (>15 pack years)
研究组 & 干预措施
Study group
50 participants (25 female, 25 male) who are physically active for at least 150 minutes per week, at a moderate activity level.
干预措施: Graded Exercise Test (Diagnostic Test)
Study group
50 participants (25 female, 25 male) who are physically active for at least 150 minutes per week, at a moderate activity level.
干预措施: Graded Hypoxia Exercise Test (Diagnostic Test)
结局指标
主要结局
PaO₂/FiO₂ Ratio
时间窗: 30 minutes
The PaO₂/FiO₂ ratio is a widely used measure of oxygenation efficiency in the lungs. It compares the arterial oxygen partial pressure (PaO₂, measured in mmHg) to the fraction of inspired oxygen (FiO₂, expressed as a decimal). The ratio provides insight into the ability of the lungs to transfer oxygen into the bloodstream. A PaO₂/FiO₂ ratio of 300-400 is considered to be mild hypoxemia. Participants are considered as poorly tolerating hypoxia if their ratio is \<400 and good at tolerating hypoxia if their ratio is \>400.
次要结局
未报告次要终点
研究者
Michael J. Joyner, M.D.
Principal Investigator
Mayo Clinic