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Clinical Trials/DRKS00025879
DRKS00025879Completed未知

Investigate the effects of a spermidine supplementation on immune system and inflammatory parameters in old and young adults - ImmuneAge-Study

Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)0 sites40 target enrollmentStarted: April 28, 2022Last updated:
Conditions

Trial Snapshot

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional
Allocation
Randomized controlled study
Masking
Blinded (masking used)

Eligibility Criteria

Ages
25 Years to 90 Years (—)
Sex
All

Inclusion Criteria

  • Young adults: age: 25-40 years; BMI: 20-30 kg/m²; no chronic medication except for oral contraceptives;
  • Old adults: age: 70-90 years; BMI: 20-30 kg/m²;
  • No limitations in ‘’activities of daily living’’;
  • Subjects must be able to consent as defined by law.

Exclusion Criteria

  • Pregnancy/breastfeeding;
  • Existing or past immune diseases such as leukemia, lymphoma, malignant neoplasms affecting bone marrow and lymphatic system, HIV or AIDS;
  • Self-reported severe or active medical conditions such as arteriosclerosis, advanced cardiac or respiratory disease, such as chronic obstructive pulmonary disease (COPD; GOLD-Stadium =3 (Global Initiative for Chronic Obstructive Lung Disease”-classification)) or heart failure (NYHA =3 (New York Heart Association));
  • Self-reported neurological or mental impairment;
  • Self-reported severe liver, kidney, or metabolic disease, such as liver cirrhosis (Child Pugh Score =2) or kidney disease (Stadium =3);
  • Drug/medication/alcohol dependence;
  • Existing polyamine supplementation;
  • Known intolerances or allergies to wheat germ, gluten, or histamine.

Investigators

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