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临床试验/CTRI/2025/02/081256
CTRI/2025/02/081256尚未招募不适用

A Randomised Clinical Study To Compare The Efficacy Of Lodhradi Lepa And Siddharthakadi Lepa In The Management Of Mukhdushika w.s.r. To Acne Vulgaris

Dr VJD Gramin Ayurved Mahavidyalaya1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2025年3月7日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
80
试验地点
1
主要终点
Symptoms like 1. Vedana 2. Daha 3. Shotha of Mukhadushika will be decreased with reference to Acne Vulgaris.

研究概览

简要总结

In today’s modern era due to increased competition of earning prosperity human not only adopted the new life style but also food habits of western culture which is chiefly responsible to derangement in their physiology and responsible to number of skin disease like Acne Vulgaris.(‘Mukhadushika’)

In ayurveda content sushruta has mentioned “Mukhadushika ”/ Yuvanapidika in Nidansthana 13th chapters as a separate vyadi under the one of the type of “Kshudrarogas”. In mukhdushika there is a kapha, vata, rakta dushti which leads to elevations like shalmali thorn.

Acharya Sharangdhar has mentioned yuvan pidika (Acne Vulgaris) as the mala (waste) of shukra dhatu (semen) along with vaktra snigdhata. Shukra pradurbhava (release of shukra dhatu) takes Acne is chronic inflammation of the pilosebaceous units. It is a extremely common condition, it generally starts after puberty and there are reports of it affecting over 90% of adolescents.

According to the modern science Acne is a common chronic inflammatory condition of skin. Acne affects both Males & Females,although males tend to have more with onset of puberty. Around the globe, Acne affected 80% of individuals between pubescence and 35 years of age . Acne vulgaris is disease of sebaceous gland. Patient having acne have an associated increased secretion of the sebaceous gland leading to increased oiliness of the skin. This is acted upon by the normal flora of the skin. Fatty acid along with the other components of the sebaceous (secretion )and the bacteria are responsible for producing the acne lesions. The lesion consists of Mukhdushika. comedones i.e black-heads , inflammatory papules, papule-pustules and cystic lesions. Ayurveda has described two types of Chikitsopkrama for the treatment of Mukhdushika

  1. ShodhanUpakrama

  2. Shaman Upakrama

  3. Shodhan Upakrama : It includes panchakarma in which vitiated doshas are eliminated from the body to avoid Recurrence of disease. Shodhanchikitsa includes – Vaman,Virechana,Nasya,Siravedha etc.

  4. Shaman Upakrama : The drugs which bring the equlibrium of doshas without elimination and aggrevation is Known as Shaman Chikitsa. It includes mainly 1) Internal medication 2) Local application In Local application Lepa,Pralepa,Prakshalana are common.We have decided to Bahyachikitsa which will be affordable and Practically applicable. The study will be carried out by using Lodhradi Lepa and SiddharthakadiLepa locally.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
None

入排标准

年龄范围
16.00 Year(s) 至 45.00 Year(s)(—)
性别
All

入选标准

  • Patients of either sex with age group between 16 to 45 years.
  • Patients having pitika with Ruja, Daha, Shotha and Medogarbha on face will be selected for study.
  • Patient willing to give informed consent.
  • Patient willing for clinical trial.
  • Patients may diagnosed with PCOS/PCOD.

排除标准

  • Patients with Pitika other than face.
  • Patients with age below 16 years and above 45 years.
  • Patients having disease such as Kshudrakushtha, Mahakushtha,etc.

结局指标

主要结局

Symptoms like 1. Vedana 2. Daha 3. Shotha of Mukhadushika will be decreased with reference to Acne Vulgaris.

时间窗: 7 Days, 14 Days, 21 Days, 28 Days after starting treatment

次要结局

  • Decrease in symptoms of Mukhadushika(18 Months)

研究者

发起方
Dr VJD Gramin Ayurved Mahavidyalaya
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Swapnil Ganpat Godase

Dr VJD Gramin Ayurved Mahavidyalaya Patur Akola

研究点 (1)

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