To investigate if administration of methylprednisone before surgery could decrease the incidence of urosepsis postoperative in patients with high risks undergoing percutaneous nephrolithotomy

Not Applicable

Completed

• Conditions: rosepsis after percutaneous nephrolithotomy; Infections and Infestations; Urosepsis

• Registration Number: ISRCTN16524336
• Lead Sponsor: Changhai Hospital of Shanghai

Brief Summary

2021 Results article in http://dx.doi.org/10.16781/j.0258-879x.2021.01.0021 (added 10/10/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-21
• Study Completion: 2020-03-01
• Last Update Posted: 24 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Scheduled to undergo elective percutaneous nephrolithotomy
2. History of urinary tract infection
3. Once urine culture positive
4. Count of white blood cell in urine = 500/ul
5. Aged over 17 years

Exclusion Criteria

1. Allergic to methylprednisone
2. Use corticosteroids within one month before the operation
3. Use immunodepressant
4. Fasting blood glucose more than 11 mmol/L
5. Active digestive tract ulcer
6. Emergency surgery
7. Pregnant women

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of urosepsis is recorded postoperatively by the investigator

Secondary Outcome Measures

Name	Time	Method
Incidence of systemic inflammatory response syndrome (SIRS) and uroseptic shock is recorded postoperatively by the investigator