Pterygopalatine Fossa Block in Aneurysmal Subarachnoid Hemorrhage
Early Phase 1
Completed
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal
- Interventions
- Procedure: Ptergyopalatine Fossa Block
- Registration Number
- NCT05925478
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Brief Summary
Aneurysmal subarachnoid hemorrhage (aSAH) can cause a severe headache (HA) that is famously treatment-resistant. Current pain regimens are too reliant on opioids, which results in long-term opioid dependence and can obfuscate the neurological examination, which is critical to detect vasospasm and delayed cerebral ischemia. This study will gather the initial evidence of whether the pterygopalatine fossa (PPF) regional anesthesia nerve block can treat aSAH-related HA and reduce opioid consumption in patients with aSAH.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2
Inclusion Criteria
- Aneurysmal subarachnoid hemorrhage with secured aneurysm
- Age greater than or equal to 18 years
- Able to communicate pain level
Exclusion Criteria
- Documented allergy to local anesthetics (e.g. bupivicaine)
- Patients with unsecured aneurysms
- Patients who are unable to communicate pain level (e.g. sedation/mechanical ventilation/delirium, etc)
- Medical treatment for vasospasm including blood pressure/inotropic augmentation
- Angiographic treatment for vasospasm within 48 hours
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Treatment arm Ptergyopalatine Fossa Block - Treatment arm Bupivacaine 0.25% Injectable Solution -
- Primary Outcome Measures
Name Time Method Opioid consumption 3 days Pain Rating Scale 3 days Scale of 1-10, 1 being lowest possible pain, 10 being highest possible pain
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UT Southwestern
🇺🇸Dallas, Texas, United States