effect of Itraconazole in severe asthma

Phase 2

Recruiting

• Conditions: Severe persistent asthma.; Severe persistent asthma; J45.5

• Registration Number: IRCT20091111002695N9
• Lead Sponsor: Islamic Azad University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Patients suffering from severe refractory asthma who could not be controlled by high dose corticosteroids and Long acting beta2 agonists or by antileukotrienes with or without tiotropium.
FEV1 should be less than 80 percent.

Exclusion Criteria

Allergic bronchopulmonary aspergillosis
Drug allergy
Pregnancy or Breast milk feeding
Interstitial lung disease such as Vasculitis
Recent lung infection
Gastroesophageal reflux

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bronchial Wall thickness. Timepoint: ?Before intervention and 8 months after intervention. Method of measurement: Computed tomography(CT) Scan of lung.;Transforming growth factor beta (TGF-beta) gene expression in the sputum. Timepoint: Before intervention and 8 months after intervention. Method of measurement: Detecting by Polymerase chain reaction (PCR) of the Sputum.

Secondary Outcome Measures

Name	Time	Method
Fraction of expiratory Nitric Oxide (FENO). Timepoint: Before intervention and 8 months after intervention. Method of measurement: Expiratory nitric oxide test with NObreath equipment.;Forced expiratory volume in one second (FEV1). Timepoint: Before intervention and 8 months after intervention. Method of measurement: Micro medical spirometer.;Asthma control. Timepoint: Before intervention and 8 months after intervention. Method of measurement: Asthma Control Test (ACT) score.;Number of Need for emergency services because of asthma exacerbation. Timepoint: Before intervention and 8 months after intervention. Method of measurement: Recording the date of asthma exacerbation in the Special Card which will be given to the patients.